P36051
PR
Gene name |
MCD4 (FSR2, SSU21, ZRG16, YKL165C, YKL619) |
Protein name |
GPI ethanolamine phosphate transferase 1 |
Names |
Morphogenesis checkpoint-dependent protein 4, Supersecretion of u-PA protein 21 |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL165C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P36051
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P36051-F1 | Predicted | AlphaFoldDB |
9 variants for P36051
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-140693 | 2 | W>G | No | SGRP | |
| s11-140222 | 159 | A>T | No | SGRP | |
| s11-139537 | 387 | I>T | No | SGRP | |
| s11-139240 | 486 | D>A | No | SGRP | |
| s11-139045 | 551 | P>L | No | SGRP | |
| s11-138872 | 609 | L>F | No | SGRP | |
| s11-138629 | 690 | V>I | No | SGRP | |
| s11-138413 | 762 | M>L | No | SGRP | |
| s11-138055 | 881 | T>S | No | SGRP |
No associated diseases with P36051
Functions
7 GO annotations of cellular component
| Name | Definition |
|---|---|
| endoplasmic reticulum | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). |
| endoplasmic reticulum membrane | The lipid bilayer surrounding the endoplasmic reticulum. |
| fungal-type cell wall | A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure. |
| fungal-type vacuole | A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure. |
| Golgi membrane | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. |
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| vacuolar membrane | The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| mannose-ethanolamine phosphotransferase activity | Catalysis of the transfer of ethanolamine phosphate to a mannose residue in the GPI lipid precursor. |
| sulfuric ester hydrolase activity | Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| ATP transport | The directed movement of ATP, adenosine triphosphate, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| cell wall organization | A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. |
| GPI anchor biosynthetic process | The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol group is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MWNKTRTTLL | AVGVLFHLFY | LWSIFDIYFI | SPLVHGMSPY | QSTPTPPAKR | LFLIVGDGLR |
| 70 | 80 | 90 | 100 | 110 | 120 |
| ADTTFDKVTH | PVSGKTEFLA | PFIRSLVMNN | ATYGISHTRM | PTESRPGHVA | MIAGFYEDVS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| AVTKGWKSNP | VNFDSFFNQS | THTYSFGSPD | ILPMFKDGAS | DPNKVDTWMY | DHTFEDFTQS |
| 190 | 200 | 210 | 220 | 230 | 240 |
| SIELDAFVFR | HLDQLFHNST | LNSTLDYEIR | QDGNVFFLHL | LGCDTAGHSY | RPYSAEYYDN |
| 250 | 260 | 270 | 280 | 290 | 300 |
| VKYIDDQIPI | LIDKVNKFFA | DDKTAFIFTA | DHGMSAFGSH | GDGHPNNTRT | PLVAWGAGLN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| KPVHNPFPVS | DNYTENWELS | SIKRNDVKQA | DIASLMSYLI | GVNYPKNSVG | ELPIAYIDGK |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ESDKLAALYN | NARSILEQYL | VKQDEVIDSQ | FFYKEYFKFV | EKSHSHYLEE | IETLIQRISE |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GENYLEQEAI | TLTEELMQIT | LEGLHYLTTY | NWRFIRTIVT | FGFVGWIFFS | FIIFLKSFIL |
| 490 | 500 | 510 | 520 | 530 | 540 |
| ENVIDDQKAS | PLSHAVFGSI | GILLNWILFY | QHSPFNFYMY | LLFPLYFWSY | IFTNRSVLRS |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GIKEFFKGTS | PWKRVLITIS | IISVYEGIVY | GFFHRWTFTL | ITNILAFYPF | ICGVRELSVN |
| 610 | 620 | 630 | 640 | 650 | 660 |
| ILWIITSVLL | STFTLFDAVK | IEDLNQIHLA | GLLIILSAFY | ALYKIHSRIN | SYTRAIFAIQ |
| 670 | 680 | 690 | 700 | 710 | 720 |
| ISLVAAMLAV | THRSVISLQL | RQGLPRESQV | AGWIIFFVSL | FVMPILHYRK | PNNDYKVRLL |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IIYLTFAPSF | IILTISFESL | FYFLFTSYMV | QWIEIENKIK | EMKTQKDENW | LQVLRVSVIG |
| 790 | 800 | 810 | 820 | 830 | 840 |
| FFLLQVAFFG | TGNVASISSF | SLESVCRLLP | IFDPFLMGAL | LMLKLIIPYG | LLSTCLGILN |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LKLNFKDYTI | SSLIISMSDI | LSLNFFYLLR | TEGSWLDIGI | TISNYCLAIL | SSLFMLILEV |
| 910 | |||||
| LGHVLLKNVI | IQDKTKKTQ |