P36037

PR
Gene name
DOA1
Protein name
Protein DOA1
Names
Degradation of alpha protein 1, Ubiquitin fusion degradation protein 3
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YKL213C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

265-346 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P36037

Entry ID Method Resolution Chain Position Source
3GAE X-ray 160 A A/B 464-715 PDB
3L3F X-ray 190 A X 354-715 PDB
3ODT X-ray 135 A A/B 2-300 PDB
3PSP X-ray 242 A A 325-715 PDB
3PST X-ray 200 A A 325-715 PDB
AF-P36037-F1 Predicted AlphaFoldDB

13 variants for P36037

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-34105 2 G>R No SGRP
s11-33867 81 V>E No SGRP
s11-33535 192 H>Y No SGRP
s11-33220 297 E>Q No SGRP
s11-32977 378 I>V No SGRP
s11-32889 407 S>N No SGRP
s11-32863 416 N>D No SGRP
s11-32734 459 S>P No SGRP
s11-32447 554 K>N No SGRP
s11-32205 635 K>R No SGRP
s11-32125 662 E>K No SGRP
s11-32073 679 T>N No SGRP
s11-32055 685 R>K No SGRP

No associated diseases with P36037

10 regional properties for P36037

Type Name Position InterPro Accession
repeat WD40 repeat 2 - 40 IPR001680-1
repeat WD40 repeat 88 - 125 IPR001680-2
repeat WD40 repeat 126 - 166 IPR001680-3
repeat WD40 repeat 167 - 206 IPR001680-4
repeat WD40 repeat 209 - 288 IPR001680-5
domain PUL domain 465 - 715 IPR013535
domain PLAA family ubiquitin binding domain 333 - 449 IPR015155
repeat G-protein beta WD-40 repeat 27 - 41 IPR020472-1
repeat G-protein beta WD-40 repeat 153 - 167 IPR020472-2
repeat G-protein beta WD-40 repeat 234 - 248 IPR020472-3

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
  • Mitochondrion outer membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Endosome membrane ; Peripheral membrane protein ; Cytoplasmic side
  • Predominantly localizes to the cytoplasm
  • Probably localizes to endosomes and mitochondria in a transient manner
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytoplasmic side of mitochondrial outer membrane The external (cytoplasmic) face of the mitochondrial outer membrane.
endosome membrane The lipid bilayer surrounding an endosome.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

3 GO annotations of molecular function

Name Definition
protein-containing complex binding Binding to a macromolecular complex.
ubiquitin binding Binding to ubiquitin, a protein that when covalently bound to other cellular proteins marks them for proteolytic degradation.
ubiquitin-dependent protein binding Binding to a protein upon ubiquitination of the target protein.

5 GO annotations of biological process

Name Definition
double-strand break repair via nonhomologous end joining The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends. This term covers instances of separate pathways, called classical (or canonical) and alternative nonhomologous end joining (C-NHEJ and A-NHEJ). These in turn may further branch into sub-pathways, but evidence is still unclear.
mitochondria-associated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of proteins transported from mitochondria and targeted to cytoplasmic proteasomes for degradation as a response to oxidative stress conditions.
proteasome-mediated ubiquitin-dependent protein catabolic process The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.
ribophagy The selective autophagy process in which cells degrade mature ribosomes under conditions of starvation.
ubiquitin recycling Any process involved in the maintenance of an internal steady state of ubiquitin monomers and free ubiquitin chains at the level of the cell by recycling ubiquitin from proteasome-bound ubiquitinated intermediates.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q969H0 FBXW7 F-box/WD repeat-containing protein 7 Homo sapiens (Human) PR
10 20 30 40 50 60
MGYQLSATLK GHDQDVRDVV AVDDSKVASV SRDGTVRLWS KDDQWLGTVV YTGQGFLNSV
70 80 90 100 110 120
CYDSEKELLL FGGKDTMING VPLFATSGED PLYTLIGHQG NVCSLSFQDG VVISGSWDKT
130 140 150 160 170 180
AKVWKEGSLV YNLQAHNASV WDAKVVSFSE NKFLTASADK TIKLWQNDKV IKTFSGIHND
190 200 210 220 230 240
VVRHLAVVDD GHFISCSNDG LIKLVDMHTG DVLRTYEGHE SFVYCIKLLP NGDIVSCGED
250 260 270 280 290 300
RTVRIWSKEN GSLKQVITLP AISIWSVDCM SNGDIIVGSS DNLVRIFSQE KSRWASEDEI
310 320 330 340 350 360
NELSTQVEKS TISSKTIEFD ESKLSPYEIL QSPGRKEGQI VVVKSPQGTI EAHQFSNSSW
370 380 390 400 410 420
KKVGDVVGAG ATGNDKKIEF EGKTYDYVFD VDIEDGKPPL KLPINVSDNP YTAADNFLAR
430 440 450 460 470 480
YELPMSYRDQ VVQFILKNTN GISLDQPNDN ASSSAVSPSK TSVMKVLPVK QYLIMENYNP
490 500 510 520 530 540
DTIFNGIVKI NSNEKTFDDE ILAQIGGALH DIDESWELLL SFANTIRSNW EIKTPAYDIV
550 560 570 580 590 600
RLIVKKLPYS SDIKDYIEEG LGNKNITLTM LTVRILVNCF NNENWGVKLL ESNQVYKSIF
610 620 630 640 650 660
ETIDTEFSQA SAKQSQNLAI AVSTLIFNYS ALVTKGNSDL ELLPIVADAI NTKYGPLEEY
670 680 690 700 710
QECEEAAYRL TVAYGNLATV EPTLRQFANS VTWLANIKRS YGNVPRFKDI FDDLS