P36024

PR
Gene name
SIS2 (HAL3, YKR072C)
Protein name
Phosphopantothenoylcysteine decarboxylase subunit SIS2
Names
Halotolerance protein HAL3, Sit4 suppressor 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YKR072C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

472-562 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P36024

Entry ID Method Resolution Chain Position Source
AF-P36024-F1 Predicted AlphaFoldDB

6 variants for P36024

Variant ID(s) Position Change Description Diseaes Association Provenance
s11-577421 115 D>E No SGRP
s11-577411 119 T>A No SGRP
s11-577102 222 G>R No SGRP
s11-577086 227 R>H No SGRP
s11-577068 233 T>M No SGRP
s11-576125 547 E>D No SGRP

No associated diseases with P36024

1 regional properties for P36024

Type Name Position InterPro Accession
domain Flavoprotein 265 - 488 IPR003382

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
CoA-synthesizing protein complex A multisubunit complex likely involved in the synthesis of coenzyme A (CoA). In S. cerevisiae, the complex consists of at least Cab2, Cab3, Cab4 and Cab5 but may also include Sis2 and Vhs3. The latter subunits are shared by the GO:0071513 phosphopantothenoylcysteine decarboxylase complex that catalyses the third step of the coenzyme A (CoA) biosynthetic pathway.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
phosphopantothenoylcysteine decarboxylase complex A protein complex that catalyzes decarboxylation of 4'-phosphopantothenoylcysteine to yield 4'-phosphopantetheine; this is the third step in the biosynthesis of Coenzyme A. The complex is homotrimeric in many eukaryotes, but is a heterotrimer in Saccharomyces.

4 GO annotations of molecular function

Name Definition
catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
identical protein binding Binding to an identical protein or proteins.
protein serine/threonine phosphatase inhibitor activity Binds to and stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate.

4 GO annotations of biological process

Name Definition
coenzyme A biosynthetic process The chemical reactions and pathways resulting in the formation of coenzyme A, 3'-phosphoadenosine-(5')diphospho(4')pantatheine, an acyl carrier in many acylation and acyl-transfer reactions in which the intermediate is a thiol ester.
negative regulation of phosphoprotein phosphatase activity Any process that stops or reduces the activity of a phosphoprotein phosphatase.
regulation of mitotic cell cycle Any process that modulates the rate or extent of progress through the mitotic cell cycle.
response to salt stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTAVASTSGK QDADHNQSIE CPRFSRGQKE ILLDHEDAKG KDSIINSPVS GRQSISPTLS
70 80 90 100 110 120
NATTTTTKSI MNATGTSGAV VSNTPEPGLK RVPAVTFSDL KQQQKQDSLT QLKNDSERTK
130 140 150 160 170 180
SPNSNPAPVS NSIPGNHAVI PNHTNTSRTT QLSGSPLVNE MKDYDPKKKD SALKIVDTMK
190 200 210 220 230 240
PDKIMATSTP ISRENNKVTA KAPTSITLRK EDAQDQANNV SGQINVRSTP EETPVKQSVI
250 260 270 280 290 300
PSIIPKRENS KNLDPRLPQD DGKLHVLFGA TGSLSVFKIK PMIKKLEEIY GRDRISIQVI
310 320 330 340 350 360
LTQSATQFFE QRYTKKIIKS SEKLNKMSQY ESTPATPVTP TPGQCNMAQV VELPPHIQLW
370 380 390 400 410 420
TDQDEWDAWK QRTDPVLHIE LRRWADILVV APLTANTLSK IALGLCDNLL TSVIRAWNPS
430 440 450 460 470 480
YPILLAPSMV SSTFNSMMTK KQLQTIKEEM SWVTVFKPSE KVMDINGDIG LGGMMDWNEI
490 500 510 520 530 540
VNKIVMKLGG YPKNNEEEDD DEDEEEDDDE EEDTEDKNEN NNDDDDDDDD DDDDDDDDDD
550 560
DDDDDDEDED EAETPGIIDK HQ