P35810

PR
Gene name
gyrA
Protein name
DNA gyrase subunit A
Names
Species
Fibrobacter succinogenes (strain ATCC 19169 / S85)
KEGG Pathway
fsu:Fisuc_0363
EC number
5.6.2.2: Enzymes altering nucleic acid conformation
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

838-903 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P35810

Entry ID Method Resolution Chain Position Source
AF-P35810-F1 Predicted AlphaFoldDB

No variants for P35810

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P35810

No associated diseases with P35810

7 regional properties for P35810

Type Name Position InterPro Accession
domain DNA topoisomerase, type IIA, domain A 13 - 475 IPR002205
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 505 - 548 IPR006691-1
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 555 - 603 IPR006691-2
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 612 - 654 IPR006691-3
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 709 - 754 IPR006691-4
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 760 - 806 IPR006691-5
repeat DNA gyrase/topoisomerase IV, subunit A, C-terminal repeat 811 - 853 IPR006691-6

Functions

Description
EC Number 5.6.2.2 Enzymes altering nucleic acid conformation
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
chromosome A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA negative supercoiling activity Catalytic introduction of negative supercoils into a DNA molecule or region thereof. In bacteria, negative supercoils are only introduced by DNA gyrase, a type II topoisomerase, but not all DNA gyrases are capable of introducing supercoils. In bacteria, the level of supercoiling varies widely between species and has been characterized properly in only a handful of organisms. The best characterized enzyme, from E.coli, is exceptionally proficient at supercoiling and this ability is not representative of all bacteria.

2 GO annotations of biological process

Name Definition
DNA topological change The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number.
DNA-templated DNA replication A DNA replication process that uses parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSEEMVPGSQ FKSLVEQDMQ DCYLRYSMSV IVARALPDAR DGFKPVHRRV MYSMHKLGVV
70 80 90 100 110 120
PNKGTVKSAR IVGDVIGKYH PHGDVAVYDT LARMAQDFSL RYPLVFGQGN FGSIDGDSPA
130 140 150 160 170 180
AMRYTEAKMN NLGALMLEDL EKETVDMGPN YDESLEEPLV LPSALPNMIV NGTSGIAVGM
190 200 210 220 230 240
ATNMAPHNLR EVGAAIHALA ENPDLTGEDL MEYVKGPDFP TGAIVCGRSG IREAYLTGHG
250 260 270 280 290 300
RVRVRARTEI ETDAKGKPRI IVTEIPYMVN KAELCKKIAD LVRDKRIDGI TDIRDESSRD
310 320 330 340 350 360
IRIVIELRRD AVGEVVLNNL FKYTQLQTTF SIYNLALVNN LPKLLTLKDL LQVYIDHRLD
370 380 390 400 410 420
VITRATQFDL KKAAARLHII EGLRIATQNI DEVVKIIRQS KTTEIAKQSL QDRFSLDEIQ
430 440 450 460 470 480
SQAIVDMRLA QLVGLNIEKL EAEYNELIAT VADLKDILEK RERRVAIMLQ KLDAVVDKYG
490 500 510 520 530 540
DERRTTIGEA IDDSDDEDLI AEEEQVITLS KEGYIRRLPI DTFKAQNRGG KGIIGAGLKD
550 560 570 580 590 600
EDNVEQIFTA STHSYLLVFT NKGRVYWTKV YRLPEGARNG KGRPIVNFVA LTEGEKVQAI
610 620 630 640 650 660
VPVRKFGGYF CLVFATKKGI INKMDLTLFS RPRKAGVNAI SLDEDDELVK VQLVGMSAEE
670 680 690 700 710 720
YEASKNASDD DSAEAVENAA EAQAAEAAIA EESESGDAED FANRPIPKDL LMIATKNGQA
730 740 750 760 770 780
VTFPISCFRA MGRGTHGVKG ITLAEGDEVI SLLWLKAGNK ILTITEKGYG KRSEPGSYRV
790 800 810 820 830 840
TRRGSKGVRN LNVTDKIGAA VFVESVADDY DLIITSKDGQ VIRIKAADIR LTGRNAQGVK
850 860 870 880 890 900
AITLRDGDVV KDATALPSVE DIEQDSADAK ETFDKVKGVE VDDDSVVKDD AEKQEIGPTE
TEE