P35728
Gene name |
MPE1 (YKL059C, YKL316) |
Protein name |
Protein MPE1 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YKL059C |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
4 structures for P35728
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 6I1D | X-ray | 228 A | B | 1-160 | PDB |
| 7ZGP | EM | 270 A | F | 1-441 | PDB |
| 7ZGR | EM | 260 A | F | 1-441 | PDB |
| AF-P35728-F1 | Predicted | AlphaFoldDB |
4 variants for P35728
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s11-328729 | 120 | T>I | No | SGRP | |
| s11-328195 | 298 | R>K | No | SGRP | |
| s11-328033 | 352 | T>M | No | SGRP | |
| s11-327794 | 432 | P>S | No | SGRP |
No associated diseases with P35728
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| mRNA cleavage and polyadenylation specificity factor complex | A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal. |
| nucleus | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. |
3 GO annotations of molecular function
| Name | Definition |
|---|---|
| pre-mRNA binding | Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule. |
| ubiquitin protein ligase activity | Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues. |
| zinc ion binding | Binding to a zinc ion (Zn). |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| mRNA polyadenylation | The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript. |
| pre-mRNA cleavage required for polyadenylation | The targeted, endonucleolytic cleavage of a pre-mRNA, required for polyadenylation of the 3' end. This cleavage is directed by binding sites near the 3' end of the mRNA and leaves a 3' hydoxyl end which then becomes a target for adenylation. |
| protein polyubiquitination | Addition of multiple ubiquitin groups to a protein, forming a ubiquitin chain. |
| protein ubiquitination | The process in which one or more ubiquitin groups are added to a protein. |
| termination of RNA polymerase II transcription, poly(A)-coupled | An RNA polymerase II transcription termination process in which cleavage and polyadenylylation of the mRNA 3' end are coupled to transcription termination. |
| ubiquitin-dependent protein catabolic process | The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin group, or multiple ubiquitin groups, to the protein. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSSTIFYRFK | SQRNTSRILF | DGTGLTVFDL | KREIIQENKL | GDGTDFQLKI | YNPDTEEEYD |
| 70 | 80 | 90 | 100 | 110 | 120 |
| DDAFVIPRST | SVIVKRSPAI | KSFSVHSRLK | GNVGAAALGN | ATRYVTGRPR | VLQKRQHTAT |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TTANVSGTTE | EERIASMFAT | QENQWEQTQE | EMSAATPVFF | KSQTNKNSAQ | ENEGPPPPGY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| MCYRCGGRDH | WIKNCPTNSD | PNFEGKRIRR | TTGIPKKFLK | SIEIDPETMT | PEEMAQRKIM |
| 250 | 260 | 270 | 280 | 290 | 300 |
| ITDEGKFVVQ | VEDKQSWEDY | QRKRENRQID | GDETIWRKGH | FKDLPDDLKC | PLTGGLLRQP |
| 310 | 320 | 330 | 340 | 350 | 360 |
| VKTSKCCNID | FSKEALENAL | VESDFVCPNC | ETRDILLDSL | VPDQDKEKEV | ETFLKKQEEL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| HGSSKDGNQP | ETKKMKLMDP | TGTAGLNNNT | SLPTSVNNGG | TPVPPVPLPF | GIPPFPMFPM |
| 430 | 440 | ||||
| PFMPPTATIT | NPHQADASPK | K |