P35688

PR
Gene name
LRG1 (YDL240W)
Protein name
Rho-GTPase-activating protein LRG1
Names
LIM-RhoGAP protein 1
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YDL240W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

493-601 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P35688

Entry ID Method Resolution Chain Position Source
AF-P35688-F1 Predicted AlphaFoldDB

22 variants for P35688

Variant ID(s) Position Change Description Diseaes Association Provenance
s04-22874 18 T>A No SGRP
s04-22889 23 N>H No SGRP
s04-22928 36 I>V No SGRP
s04-23066 82 S>P No SGRP
s04-23097 92 R>K No SGRP
s04-23241 140 G>E No SGRP
s04-23356 178 H>Q No SGRP
s04-23552 244 L>I No SGRP
s04-23744 308 I>V No SGRP
s04-23850 343 N>S No SGRP
s04-23981 387 P>A No SGRP
s04-24141 440 I>T No SGRP
s04-24172 450 K>N No SGRP
s04-24403 527 M>I No SGRP
s04-24564 581 S>N No SGRP
s04-24841 673 L>F No SGRP
s04-25195 791 N>K No SGRP
s04-25295 825 I>L No SGRP
s04-25365 848 R>H No SGRP
s04-25814 998 K>E No SGRP
s04-25820 1000 P>S No SGRP
s04-25835 1005 D>N No SGRP

No associated diseases with P35688

4 regional properties for P35688

Type Name Position InterPro Accession
domain Rho GTPase-activating protein domain 730 - 953 IPR000198
domain Zinc finger, LIM-type 26 - 96 IPR001781-1
domain Zinc finger, LIM-type 97 - 148 IPR001781-2
domain Zinc finger, LIM-type 417 - 481 IPR001781-3

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm
  • Bud
  • Bud neck
  • Localized to the bud site during bud formation and at the bud neck during cytokinesis
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

7 GO annotations of cellular component

Name Definition
cellular bud neck The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
cellular bud tip The end of a cellular bud distal to the site of attachment to the mother cell.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
incipient cellular bud site The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence.
mating projection tip The apex of the mating projection in unicellular fungi exposed to mating pheromone; site of polarized growth.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.
site of polarized growth Any part of a cell where non-isotropic growth takes place.

2 GO annotations of molecular function

Name Definition
GTPase activator activity Binds to and increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP.
metal ion binding Binding to a metal ion.

9 GO annotations of biological process

Name Definition
actin cytoskeleton organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.
cytogamy During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae.
negative regulation of protein kinase C signaling Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.
negative regulation of Rho protein signal transduction Any process that stops, prevents, or reduces the frequency, rate or extent of Rho protein signal transduction.
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
regulation of cell wall (1->3)-beta-D-glucan biosynthetic process Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells.
regulation of fungal-type cell wall organization Any process that modulates the rate, frequency or extent of the formation, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
sporulation resulting in formation of a cellular spore The process in which a relatively unspecialized cell acquires the specialized features of a cellular spore, a cell form that can be used for dissemination, for survival of adverse conditions because of its heat and dessication resistance, and/or for reproduction.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MIQNSAGYRS LNTASPMTVQ VKNQKKICAR CNKLVIPDSQ RTKTTLKALG KYYHESCFTC
70 80 90 100 110 120
QDCQKPLKPK YFPYQVDKTS ESILLCQYDY FRRHNLLCHV CDTPLRGLYY TAFGYRYDEE
130 140 150 160 170 180
HFSCTICATP CGVKKCFMYG NQLYCKYHFL KYFSKRCKGC EFPISDQYIE FPKGEEIHCW
190 200 210 220 230 240
HPECYGIHKY WHVNLAAETV GLQYLPKLEY NPNSGDKDIN PTAYELDKQM QAFNFILSKT
250 260 270 280 290 300
WSVLYRFEEE AASCISDMFQ YLTSNDQLKG IESTGLLVLK IDCLFRGLDT LNLSTNKSMP
310 320 330 340 350 360
VNSDQECIEN NAMAASKYSK FPKNLSTKIM IYLQLLRKLG TENKNETITI SSFMSVITGL
370 380 390 400 410 420
AHFLKLLTRF GLYTALENNK LTHSVNPLLR FLREVEKNEL FENNPFQYIK TPVNATDSCA
430 440 450 460 470 480
GCNKYIQEEC IQFYEHRWHI ACFTCSSCHK NINPRSLTDP TFNKEKKKIL CSHCSIDDPA
490 500 510 520 530 540
SVPGFKFVTK LAQLIFLLKI ALVKSRTVML KSKASNKVGR NSLQSTMLKE QTYIRTLNDI
550 560 570 580 590 600
KRLRSRRESV RVTHNKQQAR KSVILETAET DLNDPTKQGD SKNLVIQTDD PSSSQQVSTR
610 620 630 640 650 660
ENVFSNTKTL TLDDISRIVA AEQARELRPN AFAHFKKLKE TDDETSNVVP KKSGVYYSEL
670 680 690 700 710 720
STMELSMIRA ISLSLLAGKQ LISKTDPNYT SLVSMVFSNE KQVTGSFWNR MKIMMSMEPK
730 740 750 760 770 780
KPITKTVFGA PLDVLCEKWG VDSDLGVGPV KIRIPIIIDE LISSLRQMDM SVEGIFRKNG
790 800 810 820 830 840
NIRRLRELTA NIDSNPTEAP DFSKENAIQL SALLKKFIRE LPQPILSTDL YELWIKAAKI
850 860 870 880 890 900
DLEDEKQRVI LLIYSLLPTY NRNLLEALLS FLHWTSSFSY IENEMGSKMD IHNLSTVITP
910 920 930 940 950 960
NILYLRHKEI SNDNVPDEPE SGLVDSFAQN KGENYFLAIE IVDYLITHNE EMAMVPKFLM
970 980 990 1000 1010
NLLKDVQLQK LDNYESINHF ISTVMQSKTI DYSECDIKTP VTVKDSTTTV IQGEINK