P35207

PR
Gene name
SKI2 (YLR398C, L8084.17)
Protein name
Antiviral helicase SKI2
Names
Superkiller protein 2
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR398C
EC number
3.6.4.13: Acting on ATP; involved in cellular and subcellular movement
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

97-331 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P35207

Entry ID Method Resolution Chain Position Source
4A4K X-ray 325 A A/C/E/G/I 835-1085 PDB
4A4Z X-ray 240 A A 296-1287 PDB
4BUJ X-ray 370 A PDB
5MC6 EM 380 A h 1-1287 PDB
8Q9T EM 284 A A 1-1287 PDB
8QCA EM 284 A A 1-1287 PDB
8QCB EM 280 A A 1-1287 PDB
8QCF EM 255 A M 1-851 PDB
AF-P35207-F1 Predicted AlphaFoldDB

11 variants for P35207

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-918893 43 E>K No SGRP
s12-918511 170 D>G No SGRP
s12-918482 180 A>P No SGRP
s12-918434 196 I>V No SGRP
s12-918349 224 K>R No SGRP
s12-918322 233 L>S No SGRP
s12-918280 247 E>G No SGRP
s12-918026 332 T>S No SGRP
s12-917305 572 D>G No SGRP
s12-915889 1044 D>G No SGRP
s12-915461 1187 C>S No SGRP

No associated diseases with P35207

6 regional properties for P35207

Type Name Position InterPro Accession
domain Helicase, C-terminal 638 - 815 IPR001650
domain DEAD/DEAH box helicase domain 333 - 481 IPR011545
domain ATP-dependent RNA helicase Ski2/MTR4, C-terminal 1106 - 1287 IPR012961
domain Helicase superfamily 1/2, ATP-binding domain 326 - 513 IPR014001
domain rRNA-processing arch domain 823 - 1083 IPR025696
domain Ski2, N-terminal domain 84 - 215 IPR040801

Functions

Description
EC Number 3.6.4.13 Acting on ATP; involved in cellular and subcellular movement
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
Ski complex A protein complex that regulates RNA degradation by the exosome complex. In Saccharomyces the complex has a heterotetrameric stoichiometry consisting of one copy each of Ski2p and Ski3 and two copies of Ski8p.

5 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
ATP hydrolysis activity Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
mRNA binding Binding to messenger RNA (mRNA), an intermediate molecule between DNA and protein. mRNA includes UTR and coding sequences, but does not contain introns.
RNA helicase activity Unwinding of an RNA helix, driven by ATP hydrolysis.

7 GO annotations of biological process

Name Definition
defense response to virus Reactions triggered in response to the presence of a virus that act to protect the cell or organism.
mRNA catabolic process The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes.
nuclear-transcribed mRNA catabolic process, 3'-5' exonucleolytic nonsense-mediated decay The chemical reactions and pathways resulting in the breakdown of the nuclear-transcribed mRNA transcript body of an mRNA in which an amino-acid codon has changed to a nonsense codon; occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
nuclear-transcribed mRNA catabolic process, exonucleolytic, 3'-5' The chemical reactions and pathways resulting in the breakdown of the mRNA transcript body that occurs when the 3' end is not protected by a 3'-poly(A) tail; degradation proceeds in the 3' to 5' direction.
nuclear-transcribed mRNA catabolic process, non-stop decay The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that is lacking a stop codon.
regulation of translation Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA or circRNA.
RNA catabolic process The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q15477 SKIV2L Helicase SKI2W Homo sapiens (Human) PR
10 20 30 40 50 60
MSEGFSSSSI QELYQSLKEI TNNADVELFE DRITKLDFES TDEPKHANDI IKDRFLRPSN
70 80 90 100 110 120
ALPWSLLDMV QDVPHTSSPE DCSGKLDYKE LLKVPDPINR TSYQFKRTGL EGKISGYKEE
130 140 150 160 170 180
VDLKEVANAN ASNSLSITRS INHNQNSVRG STAQLPFTPG GIPMKSVKTD SEQNGSSTMA
190 200 210 220 230 240
NATKLLHKDG QGLFDIPEGM NRGIKPMDSP AENEDQNGQF KELKQLNEID NELDIRIEAN
250 260 270 280 290 300
EAKLKEEEKS AKSISEEIME EATEETTADN ADDAEIDELL PIGIDFGRTK PVSKSVPVKK
310 320 330 340 350 360
EWAHVVDLNH KIENFDELIP NPARSWPFEL DTFQKEAVYH LEQGDSVFVA AHTSAGKTVV
370 380 390 400 410 420
AEYAIAMAHR NMTKTIYTSP IKALSNQKFR DFKETFDDVN IGLITGDVQI NPDANCLIMT
430 440 450 460 470 480
TEILRSMLYR GADLIRDVEF VIFDEVHYVN DQDRGVVWEE VIIMLPQHVK FILLSATVPN
490 500 510 520 530 540
TYEFANWIGR TKQKNIYVIS TPKRPVPLEI NIWAKKELIP VINQNSEFLE ANFRKHKEIL
550 560 570 580 590 600
NGESAKGAPS KTDNGRGGST ARGGRGGSNT RDGRGGRGNS TRGGANRGGS RGAGAIGSNK
610 620 630 640 650 660
RKFFTQDGPS KKTWPEIVNY LRKRELLPMV VFVFSKKRCE EYADWLEGIN FCNNKEKSQI
670 680 690 700 710 720
HMFIEKSITR LKKEDRDLPQ ILKTRSLLER GIAVHHGGLL PIVKELIEIL FSKGFIKVLF
730 740 750 760 770 780
ATETFAMGLN LPTRTVIFSS IRKHDGNGLR ELTPGEFTQM AGRAGRRGLD STGTVIVMAY
790 800 810 820 830 840
NSPLSIATFK EVTMGVPTRL QSQFRLTYNM ILNLLRIEAL RVEEMIKYSF SENAKETLQP
850 860 870 880 890 900
EHEKQIKVLQ EELQTIEYKS CEICDNDIEK FLELMLAYKE ATVNLMQEMV KSPSILHILK
910 920 930 940 950 960
EGRLVAFRDP NDCLKLGFVF KVSLKDAVCV IMTFTKPYKL PNGEPNHLIY FPKADGYRRR
970 980 990 1000 1010 1020
NFPKFQKTDF YMEEVPVTAI EVITKRKFAA PLGKVIKKDV AALNEFNAET NNILDGKTLK
1030 1040 1050 1060 1070 1080
EAINIEKQGL KIHQILLDRT NIRDEIFKLK SIKCPNLSQH IVPKFKAHVI KKKIEELYHL
1090 1100 1110 1120 1130 1140
MSDQNLSLLP DYEKRLAVLK DTEFIDQNHN VLLKGRVACE INSGYELVLT ELILDNFLGS
1150 1160 1170 1180 1190 1200
FEPEEIVALL SVFVYEGKTR EEEPPIVTPR LAKGKQRIEE IYKKMLCVFN THQIPLTQDE
1210 1220 1230 1240 1250 1260
AEFLDRKRFA MMNVVYEWAR GLSFKEIMEM SPEAEGTVVR VITWLDEICR EVKTASIIIG
1270 1280
NSTLHMKMSR AQELIKRDIV FAASLYL