P35203

PR
Gene name
CTF13 (CBF3C, YMR094W, YM6543.01, YM9582.19)
Protein name
Centromere DNA-binding protein complex CBF3 subunit C
Names
Chromosome transmission fidelity protein 13, Kinetochore protein CTF13
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YMR094W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

177-282 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P35203

Entry ID Method Resolution Chain Position Source
6FE8 EM 370 A D 2-478 PDB
6GSA EM 420 A D 2-478 PDB
6GYP EM 360 A A 1-478 PDB
6GYS EM 440 A A/H 1-478 PDB
6GYU EM 300 A A 1-478 PDB
7K79 EM 400 A K 2-478 PDB
8OW1 EM 370 A CT 1-478 PDB
AF-P35203-F1 Predicted AlphaFoldDB

11 variants for P35203

Variant ID(s) Position Change Description Diseaes Association Provenance
s13-455855 11 E>G No SGRP
s13-455857 12 L>V No SGRP
s13-455969 49 G>E No SGRP
s13-456188 122 Y>F No SGRP
s13-456455 211 K>R No SGRP
s13-456566 248 V>A No SGRP
s13-456637 272 S>G No SGRP
s13-456839 339 L>* No SGRP
s13-457012 397 S>G No SGRP
s13-457081 420 Q>E No SGRP
s13-457246 475 V>I No SGRP

No associated diseases with P35203

No regional properties for P35203

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P35203

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
  • Chromosome, centromere
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
CBF3 complex A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p.
kinetochore A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.

1 GO annotations of molecular function

Name Definition
DNA binding, bending The activity of binding selectively and non-covalently to and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence.

2 GO annotations of biological process

Name Definition
kinetochore assembly The aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.
septin ring assembly The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MPSFNPVRFL ELPIDIRKEV YFHLDGNFCG AHPYPIDILY KSNDVELPGK PSYKRSKRSK
70 80 90 100 110 120
KLLRYMYPVF ATYLNIFEYS PQLIEKWLEY AFWLRYDCLV LDCFKVNHLY DGTLIDALEW
130 140 150 160 170 180
TYLDNELRLA YFNKASMLEV WYTFKEYKKW VIDSVAFDEL DLLNVSNIQF NIDNLTPQLV
190 200 210 220 230 240
DKCLSILEQK DLFATIGEVQ FGQDEEVGEE KDVDVSGANS DENSSPSSTI KNKKRSASKR
250 260 270 280 290 300
SHSDNGNVGA THNQLTSISV IRTIRSMESM KSLRKITVRG EKLYELLINF HGFRDNPGKT
310 320 330 340 350 360
ISYIVKRRIN EIRLSRMNQI SRTGLADFTR WDNLQKLVLS RVAYIDLNSI VFPKNFKSLT
370 380 390 400 410 420
MKRVSKIKWW NIEENILKEL KVDKRTFKSL YIKEDDSKFT KFFNLRHTRI KELDKSEINQ
430 440 450 460 470
ITYLRCQAIV WLSFRTLNHI KLQNVSEVFN NIIVPRALFD SKRVEIYRCE KISQVLVI