P35193

PR
Gene name
ATG19 (CVT19, YOL082W, O0980, YOL01)
Protein name
Autophagy-related protein 19
Names
Cytoplasm-to-vacuole targeting protein 19
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YOL082W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

95-287 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P35193

Entry ID Method Resolution Chain Position Source
2KZB NMR - A 254-367 PDB
2ZPN X-ray 270 A E/F/G/H 412-415 PDB
5JGE X-ray 191 A A/B/D/E 160-187 PDB
AF-P35193-F1 Predicted AlphaFoldDB

11 variants for P35193

Variant ID(s) Position Change Description Diseaes Association Provenance
s15-168734 3 N>I No SGRP
s15-169150 142 E>K No SGRP
s15-169250 175 N>S No SGRP
s15-169289 188 P>R No SGRP
s15-169309 195 T>A No SGRP
s15-169333 203 S>P No SGRP
s15-169355 210 T>R No SGRP
s15-169414 230 R>G No SGRP
s15-169525 267 N>D No SGRP
s15-169718 331 A>G No SGRP
s15-169772 349 K>R No SGRP

No associated diseases with P35193

1 regional properties for P35193

Type Name Position InterPro Accession
domain Signal transduction response regulator, receiver domain 91 - 209 IPR001789

Functions

Description
EC Number
Subcellular Localization
  • Preautophagosomal structure membrane ; Peripheral membrane protein
  • Also found in other perivacuolar punctate structures
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

6 GO annotations of cellular component

Name Definition
Cvt complex A protein complex that is involved in the Cvt pathway. In budding yeast, the Cvt complex consists of multimers of preApe1p.
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
phagophore assembly site Punctate structures proximal to the endoplasmic reticulum which are the sites where the Atg machinery assembles upon autophagy induction.
phagophore assembly site membrane A cellular membrane associated with the phagophore assembly site.

1 GO annotations of molecular function

Name Definition
protein-macromolecule adaptor activity The binding activity of a protein that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.

5 GO annotations of biological process

Name Definition
protein transport The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
protein-containing complex localization A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.
selective autophagy The macroautophagy process in which specific structures are targeted by the autophagy process.
ubiquitin-dependent ERAD pathway The series of steps necessary to target endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. Begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein ubiquitination necessary for correct substrate transfer, transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.
vesicle organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vesicle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNNSKTNQQM NTSMGYPLTV YDECNKFQLI VPTLDANIML WCIGQLSLLN DSNGCKHLFW
70 80 90 100 110 120
QPNDKSNVRI LLNNYDYGHL FKYLQCQRKC SVYIGEGTLK KYNLTISTSF DNFLDLTPSE
130 140 150 160 170 180
EKESLCREDA HEDPVSPKAG SEEEISPNST SNVVVSRECL DNFMKQLLKL EESLNKLELE
190 200 210 220 230 240
QKVTNKEPNH RISGTIDIPE DRSELVNFFT ELKTVKQLED VFQRYHDYER LSQECDSKTE
250 260 270 280 290 300
IASDHSKKET KIEVEPPNER SLQITMNQRD NSLYFQLFNN TNSVLAGNCK LKFTDAGDKP
310 320 330 340 350 360
TTQIIDMGPH EIGIKEYKEY RYFPYALDLE AGSTIEIENQ YGEVIFLGKY GSSPMINLRP
370 380 390 400 410
PSRLSAESLQ ASQEPFYSFQ IDTLPELDDS SIISTSISLS YDGDDNEKAL TWEEL