P34948

PR
Gene name
PMI1 (MANA, CAALFM_C209640WA, CaO19.1390)
Protein name
Mannose-6-phosphate isomerase
Names
Phosphohexomutase, Phosphomannose isomerase, PMI
Species
Candida albicans (strain SC5314 / ATCC MYA-2876) (Yeast)
KEGG Pathway
cal:CAALFM_C209640WA
EC number
5.3.1.8: Interconverting aldoses and ketoses
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

93-261 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P34948

Entry ID Method Resolution Chain Position Source
1PMI X-ray 170 A A 2-441 PDB
5NW7 X-ray 185 A A 1-441 PDB
AF-P34948-F1 Predicted AlphaFoldDB

No variants for P34948

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34948

No associated diseases with P34948

5 regional properties for P34948

Type Name Position InterPro Accession
conserved_site Phosphomannose isomerase, type I, conserved site 130 - 138 IPR018050-1
conserved_site Phosphomannose isomerase, type I, conserved site 285 - 310 IPR018050-2
domain Phosphomannose isomerase type I, C-terminal domain 348 - 398 IPR046456
domain Phosphomannose isomerase type I, catalytic domain 6 - 155 IPR046457
domain Phosphomannose isomerase type I, helical insertion domain 171 - 266 IPR046458

Functions

Description
EC Number 5.3.1.8 Interconverting aldoses and ketoses
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.

2 GO annotations of molecular function

Name Definition
mannose-6-phosphate isomerase activity Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate.
zinc ion binding Binding to a zinc ion (Zn).

5 GO annotations of biological process

Name Definition
carbohydrate metabolic process The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
cell wall mannoprotein biosynthetic process The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues.
fungal-type cell wall organization A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.
GDP-mannose biosynthetic process The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate.
protein glycosylation A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSSEKLFRIQ CGYQNYDWGK IGSSSAVAQF VHNSDPSITI DETKPYAELW MGTHPSVPSK
70 80 90 100 110 120
AIDLNNQTLR DLVTAKPQEY LGESIITKFG SSKELPFLFK VLSIEKVLSI QAHPDKKLGA
130 140 150 160 170 180
QLHAADPKNY PDDNHKPEMA IAVTDFEGFC GFKPLDQLAK TLATVPELNE IIGQELVDEF
190 200 210 220 230 240
ISGIKLPAEV GSQDDVNNRK LLQKVFGKLM NTDDDVIKQQ TAKLLERTDR EPQVFKDIDS
250 260 270 280 290 300
RLPELIQRLN KQFPNDIGLF CGCLLLNHVG LNKGEAMFLQ AKDPHAYISG DIIECMAASD
310 320 330 340 350 360
NVVRAGFTPK FKDVKNLVEM LTYSYESVEK QKMPLQEFPR SKGDAVKSVL YDPPIAEFSV
370 380 390 400 410 420
LQTIFDKSKG GKQVIEGLNG PSIVIATNGK GTIQITGDDS TKQKIDTGYV FFVAPGSSIE
430 440
LTADSANQDQ DFTTYRAFVE A