P34900

PR
Gene name
Sdc2 (Hspg1, Synd2)
Protein name
Syndecan-2
Names
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:25615
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

148-201 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34900

Entry ID Method Resolution Chain Position Source
AF-P34900-F1 Predicted AlphaFoldDB

No variants for P34900

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34900

No associated diseases with P34900

3 regional properties for P34900

Type Name Position InterPro Accession
domain Neurexin/syndecan/glycophorin C 168 - 186 IPR003585
domain Syndecan/Neurexin domain 138 - 199 IPR027789
conserved_site Syndecan, conserved site 169 - 179 IPR030479

Functions

Description
EC Number
Subcellular Localization
  • Membrane; Single-pass type I membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
cell surface The external part of the cell wall and/or plasma membrane.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
neuronal cell body The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
synapse The junction between an axon of one neuron and a dendrite of another neuron, a muscle fiber or a glial cell. As the axon approaches the synapse it enlarges into a specialized structure, the presynaptic terminal bouton, which contains mitochondria and synaptic vesicles. At the tip of the terminal bouton is the presynaptic membrane; facing it, and separated from it by a minute cleft (the synaptic cleft) is a specialized area of membrane on the receiving cell, known as the postsynaptic membrane. In response to the arrival of nerve impulses, the presynaptic terminal bouton secretes molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane.

2 GO annotations of molecular function

Name Definition
identical protein binding Binding to an identical protein or proteins.
PDZ domain binding Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins.

6 GO annotations of biological process

Name Definition
cell migration The controlled self-propelled movement of a cell from one site to a destination guided by molecular cues. Cell migration is a central process in the development and maintenance of multicellular organisms.
dendrite morphogenesis The process in which the anatomical structures of a dendrite are generated and organized.
regulation of dendrite morphogenesis Any process that modulates the frequency, rate or extent of dendrite morphogenesis.
response to caffeine Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.
response to hypoxia Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level.
wound healing The series of events that restore integrity to a damaged tissue, following an injury.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MQRAWILLTL GLMACVSAET RAELTSDKDM YLDSSSIEEA SGLYPIDDDD YSSASGSGAY
70 80 90 100 110 120
EDKGSPDLTT SQLIPRISLT SAAPEVETMT LKTQSITPTQ TESPEETDKK EFEISEAEEK
130 140 150 160 170 180
QDPAVKSTDV YTEKHSDNLF KRTEVLAAVI AGGVIGFLFA IFLILLLVYR MRKKDEGSYD
190 200
LGERKPSSAA YQKAPTKEFY A