P34389
Gene name |
ncr-2 |
Protein name |
NPC intracellular cholesterol transporter 1 homolog 2 |
Names |
Niemann-Pick C1 protein homolog 2 |
Species |
Caenorhabditis elegans |
KEGG Pathway |
cel:CELE_F09G8.4 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P34389
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P34389-F1 | Predicted | AlphaFoldDB |
No variants for P34389
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P34389 | |||||
No associated diseases with P34389
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| membrane | A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cholesterol binding | Binding to cholesterol (cholest-5-en-3-beta-ol); the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. |
| sterol binding | Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol. |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| cholesterol homeostasis | Any process involved in the maintenance of an internal steady state of cholesterol within an organism or cell. |
| cholesterol transport | The directed movement of cholesterol, cholest-5-en-3-beta-ol, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. |
| dauer larval development | The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding. |
| intestinal cholesterol absorption | Uptake of cholesterol into the blood by absorption from the small intestine. |
| sterol transport | The directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Sterols are steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. |
| vulval development | The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult. |
1 homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| Q12770 | SCAP | Sterol regulatory element-binding protein cleavage-activating protein | Homo sapiens (Human) | PR |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRQGGGGGER | MVSVLFLLLI | HLALCQAKCV | MTECDGEEDS | NHPPCKTNKS | TYLPITVTRS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| LNPTYMARFE | KYCSYLVQEE | DKAQVCCTEL | QLKGMTDRIS | NAATILGSCP | SCFDNFAKLW |
| 130 | 140 | 150 | 160 | 170 | 180 |
| CQFTCSPDQS | KFMKVMETTG | PKNVVVKMEF | KVNRDFVEGL | YESCRHTWFA | NGLALRLMSL |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GGKVSFENFY | GFMGTKNLAQ | SIPINTEFQF | SRMKNAMNIP | TTPCHKSAGP | KVPACGAIDC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PTNAHQLVDI | SKVEHLGTKV | FHPHFPDFEW | LLKICGCLAL | TVLLVFILKY | SCHRRSAPNG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| EDGCYVDLGK | GNLEVQFEGL | CARYANAVIK | HPLIFVSLGL | IVAAACCSGN | FKFHSLTHSV |
| 370 | 380 | 390 | 400 | 410 | 420 |
| DQVSAADGET | RRNEKKFIHS | FGPNHRIEQI | FINLPPTTKS | MFNMPLFEEM | FQLVGNIQNL |
| 430 | 440 | 450 | 460 | 470 | 480 |
| TACYGNSSVK | LDDICYKPIG | KNHGCAIMSP | TNYFQNKWTN | FENAGPPTID | DEIFDDQHWE |
| 490 | 500 | 510 | 520 | 530 | 540 |
| HLKYCIRNPL | TVSTYSEMSC | FGEFSGPIDP | ILVFGGSNES | IKGAEMYYTA | RTIMITVLIR |
| 550 | 560 | 570 | 580 | 590 | 600 |
| GPEDQAIAWE | TAFLNMMSRY | EMKHANFTFM | TETSVAEEIH | TAVETDKIVS | VIACAAVLIW |
| 610 | 620 | 630 | 640 | 650 | 660 |
| VITMLGINHW | PESSILSALV | HHKLLISISA | VMISVISVWC | SIGMFSLFGV | HATDNAIVVL |
| 670 | 680 | 690 | 700 | 710 | 720 |
| FFVITCLGIN | RIFVIIRTFQ | ANGHCYGLPN | ISYREMNHRI | SNVMRRSIPI | VLTNSLICST |
| 730 | 740 | 750 | 760 | 770 | 780 |
| CLFLAGGVLP | YVSVSMPAVE | VFARHAGLAI | LMDTAFYLLV | MLPLFQYDAR | REMSGKCEIW |
| 790 | 800 | 810 | 820 | 830 | 840 |
| PWYELSNESK | INLCMEAVDG | NLRSPVDWFK | LAIAPLLLKK | ICRIWIATFF | FVSLIIACYC |
| 850 | 860 | 870 | 880 | 890 | 900 |
| TLCLEFGFNQ | VMAFSETSYL | TKHFQNMNEN | LNIGPPLWFV | VEGDVKWHDP | KMQNKFCTLA |
| 910 | 920 | 930 | 940 | 950 | 960 |
| GCDDNSMGNK | IRSLAYAENY | KGNYLHGDVN | IWLDSYLQFM | HPRGSCCKMD | GKQFCDPSNA |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| THCSSCSSSS | VASLTTTEYE | FYRNLHHFLE | TPPSIQCAHG | GMALAKPAIN | LTRNGKIQSA |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| YFSTFFKKLN | LSDSIQLYDA | WRFAKYLADD | IERELEIPGV | KVYVYSTFFP | YYEQYLTLST |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| TVYTLVVLVL | FVAFVTISLF | LRVNLAGSLV | TVFVLLSSYL | HLMEWMYLLG | ITVNVVSVIN |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| MAMSLGIAVE | FFGQMLHGFY | NSKKPKREER | AFAALVSNGS | TTLSGIFPAI | MITAGCLSFA |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| DSRVLITYFC | NQLVGIGLVC | AVHGVVYMPT | LLAIFGSDFY | QNVSSEEEST | DEAELQDTPP |
| 1270 | |||||
| STTSSTSSTS | ETSV |