P34315

PR
Gene name
ncx-6 (C07A9.4)
Protein name
Putative sodium/calcium exchanger 6
Names
Na(+)/Ca(2+)-exchange protein 6
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_C07A9.4
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

230-301 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34315

Entry ID Method Resolution Chain Position Source
AF-P34315-F1 Predicted AlphaFoldDB

No variants for P34315

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34315

No associated diseases with P34315

6 regional properties for P34315

Type Name Position InterPro Accession
conserved_site Twin-arginine translocation pathway, signal sequence 1 - 32 IPR006311
domain Molybdopterin oxidoreductase 101 - 574 IPR006656
domain Molybdopterin dinucleotide-binding domain 720 - 828 IPR006657
domain Molybdopterin oxidoreductase, 4Fe-4S domain 44 - 100 IPR006963
binding_site Molybdopterin oxidoreductase, molybdopterin cofactor binding site 49 - 67 IPR027467
domain Nitrate reductase NapA-like, molybdopterin-binding domain 717 - 834 IPR041957

Functions

Description
EC Number
Subcellular Localization
  • Membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

2 GO annotations of molecular function

Name Definition
calcium:sodium antiporter activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in).
cation transmembrane transporter activity Enables the transfer of cation from one side of a membrane to the other.

2 GO annotations of biological process

Name Definition
cation transport The directed movement of cations, atoms or small molecules with a net positive charge, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
cellular calcium ion homeostasis Any process involved in the maintenance of an internal steady state of calcium ions at the level of a cell.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P34322 ncx-7 Putative sodium/calcium exchanger 7 Caenorhabditis elegans PR
10 20 30 40 50 60
MRIHFFAFLI ILSLVGCDGW QADVGKLVRK WNNQRTIDGN DIEKCIPDDG EQCTIQAGWN
70 80 90 100 110 120
STQVCEYVKC NDDNCEGGGY VLWTRYVECA SSPAVRIILI ITGVIYMLVL FIMVSSAADD
130 140 150 160 170 180
FFSPSISSIV AHLRISESVA GVTFMAFGNG APDVFGAIAS VLSSPTPKAD LALGELFGAG
190 200 210 220 230 240
LFVTTMVLAV TIFTRPFKAE VFSSIRDIAF YLVALAFLAF CFVYYDHVEI WMPITFLGVY
250 260 270 280 290 300
LIYVCTVILS QILHNRHKKD EEKVDEVKTV DTDSLEDDDD IYVSHGHHVL HAHEVMKMEA
310 320 330 340 350 360
EIEAVEPLKT WSFRGVVHDF KEHLKPWPSM DEWDEMNIFQ KVIAVLNTIP NFLFKLTIPH
370 380 390 400 410 420
SEQPWSKPIT LLQCLICPVF LLFCIQVCSI SPFPNSPGLW MYGLILSVLL TAAVLFFTEL
430 440 450 460 470 480
HKEPPFYKSL ISYAGFLMSI AWIYLISSEV VNVVTMLGVV SRVSHEVLGL TILAWSNSIG
490 500 510 520 530 540
DLIADVSVAK QGYPRMAMAA AIGGQLFNLL IGFGLPFTIA KIQGKSISMI INPTYRLLML
550 560 570 580
FLAISLIFTL IAMFAQKYFL RRIHSYSLVF IYISFFVFIG LSLDDILVWN