P34255

PR
Gene name
B0303.3
Protein name
Probable 3-ketoacyl-CoA thiolase
Names
Species
Caenorhabditis elegans
KEGG Pathway
cel:CELE_B0303.3
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-51 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34255

Entry ID Method Resolution Chain Position Source
AF-P34255-F1 Predicted AlphaFoldDB

No variants for P34255

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34255

No associated diseases with P34255

5 regional properties for P34255

Type Name Position InterPro Accession
active_site Thiolase, active site 427 - 440 IPR020610
conserved_site Thiolase, conserved site 392 - 408 IPR020613
active_site Thiolase, acyl-enzyme intermediate active site 106 - 124 IPR020615
domain Thiolase, N-terminal 26 - 298 IPR020616
domain Thiolase, C-terminal 305 - 444 IPR020617

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
acetyl-CoA C-acyltransferase activity Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA.

1 GO annotations of biological process

Name Definition
fatty acid beta-oxidation A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively).

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5R1W7 HADHB Trifunctional enzyme subunit beta, mitochondrial Pan troglodytes (Chimpanzee) PR
P55084 HADHB Trifunctional enzyme subunit beta, mitochondrial Homo sapiens (Human) PR
10 20 30 40 50 60
MLRAVSTSFG TARAASAVAK KNMPNIVLVD AVRTPFVVSG TVFKDLMAVD LQKEAIKALV
70 80 90 100 110 120
EKTKLPYEQL DHIICGTVIQ ECKTSNIARE AALLAGVPDK IPAHTVTLAC ISSNVAMTTG
130 140 150 160 170 180
MGMLATGNAN AIIAGGVELL SDVPIRYNRN ARKAMLGMNK AKDVPSKLKI GGQIVKNLLS
190 200 210 220 230 240
PELPAVAEFS TGETMGHSGD RLAAAFNVSR REQDEFAIRS HTLASEAAKN GKFTDVVPVF
250 260 270 280 290 300
LDGKKPKTIK EDNGIRVSTL EKLSSLKPAF VKPHGTVTAA NASYLTDGAS AALIMTEEYA
310 320 330 340 350 360
LANGYKPKAY LRDYLYVAQD PKDQLLLSPA YVIPKLLDKA GLTLKDVDVF EIHEAFAGQV
370 380 390 400 410 420
LANLNAMDSD YFCKEQMKRS GKFGRVPMDK LNLWGGSLSI GHPFGATGVR LATHSAHRLK
430 440
EEKGQYAVIA ACAAGGHGVG MLIEAYGK