P34227

PR
Gene name
PRX1
Protein name
Peroxiredoxin PRX1, mitochondrial
Names
Prx, 1-Cys PRX, Glutaredoxin-dependent peroxiredoxin, Glutathione-dependent peroxiredoxin, Mitochondrial thiol peroxidase, mTPx, Thioredoxin peroxidase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBL064C
EC number
1.11.1.25: Peroxidases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-82 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P34227

Entry ID Method Resolution Chain Position Source
5YKJ X-ray 153 A A 49-261 PDB
5YKW X-ray 208 A B 88-95 PDB
AF-P34227-F1 Predicted AlphaFoldDB

No variants for P34227

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34227

No associated diseases with P34227

3 regional properties for P34227

Type Name Position InterPro Accession
domain Alkyl hydroperoxide reductase subunit C/ Thiol specific antioxidant 51 - 188 IPR000866
domain Thioredoxin domain 49 - 212 IPR013766
domain Peroxiredoxin, C-terminal 209 - 245 IPR019479

Functions

Description
EC Number 1.11.1.25 Peroxidases
Subcellular Localization
  • Mitochondrion
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

3 GO annotations of molecular function

Name Definition
peroxidase activity Catalysis of the reaction: a donor + a peroxide = an oxidized donor + 2 H2O.
peroxiredoxin activity Catalysis of the reaction:
thioredoxin peroxidase activity Catalysis of the reaction:

4 GO annotations of biological process

Name Definition
cell redox homeostasis Any process that maintains the redox environment of a cell or compartment within a cell.
cellular response to oxidative stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.
regulation of hydrogen peroxide-induced cell death Any process that modulates the frequency, rate or extent of hydrogen peroxide-induced cell death.
response to cadmium ion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MFSRICSAQL KRTAWTLPKQ AHLQSQTIKT FATAPILCKQ FKQSDQPRLR INSDAPNFDA
70 80 90 100 110 120
DTTVGKINFY DYLGDSWGVL FSHPADFTPV CTTEVSAFAK LKPEFDKRNV KLIGLSVEDV
130 140 150 160 170 180
ESHEKWIQDI KEIAKVKNVG FPIIGDTFRN VAFLYDMVDA EGFKNINDGS LKTVRSVFVI
190 200 210 220 230 240
DPKKKIRLIF TYPSTVGRNT SEVLRVIDAL QLTDKEGVVT PINWQPADDV IIPPSVSNDE
250 260
AKAKFGQFNE IKPYLRFTKS K