AiPD: Autoinhibited Protein Database

Gene name	YEL1 (YBL060W, YBL0507, YBL0517)
Protein name	Guanine-nucleotide exchange factor YEL1
Names	EFA6-like protein 1
Species	Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway	sce:YBL060W
EC number
Protein Class

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

23-105 (Predicted disordered autoinhibitory region) PR

23-105 (Predicted disordered autoinhibitory region)

cis-regPred

No accessory elements

Entry ID	Method	Resolution	Chain	Position	Source
AF-P34225-F1	Predicted				AlphaFoldDB

Variant ID(s)	Position	Change	Diseaes Association	Provenance
s02-107940	3	A>P	No	SGRP
s02-107941	3	A>V	No	SGRP
s02-108151	73	T>I	No	SGRP
s02-108171	80	G>R	No	SGRP
s02-108177	82	G>S	No	SGRP
s02-108210	93	E>K	No	SGRP
s02-108241	103	S>L	No	SGRP
s02-108256	108	G>D	No	SGRP
s02-108454	174	I>K	No	SGRP
s02-108558	209	N>D	No	SGRP
s02-108559	209	N>S	No	SGRP
s02-108570	213	D>N	No	SGRP
s02-108739	269	C>Y	No	SGRP
s02-108766	278	I>T	No	SGRP
s02-109096	388	M>T	No	SGRP
s02-109137	402	P>S	No	SGRP
s02-109167	412	T>A	No	SGRP
s02-109188	419	S>T	No	SGRP
s02-109490	519	N>K	No	SGRP
s02-109546	538	H>R	No	SGRP
s02-109706	591	K>N	No	SGRP

Type	Name	Position	InterPro Accession
domain	Sec7 domain	48 - 266	IPR000904

		Description
EC Number
Subcellular Localization	Cytoplasm Cell membrane; Peripheral membrane protein Bud neck Bud tip	Localizes at the cell membrane only at the bud neck and bud tip and this localization is ARF3-dependent
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category	No pathway information available

Name	Definition
cellular bud neck	The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding.
cellular bud tip	The end of a cellular bud distal to the site of attachment to the mother cell.
cytoplasm	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
plasma membrane	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

Name	Definition
guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

Name	Definition
actin cortical patch localization	Any process in which actin cortical patches are transported to, or maintained in, a specific location. An actin cortical patch is a discrete actin-containing structure found just beneath the plasma membrane in fungal cells.
positive regulation of phosphatidylinositol biosynthetic process	Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol.
protein localization	Any process in which a protein is transported to, or maintained in, a specific location.
regulation of ARF protein signal transduction	Any process that modulates the frequency, rate or extent of ARF protein signal transduction.

UniProt AC	Gene Name	Protein Name	Species	Evidence Code
No homologous proteins