P34125

PR
Gene name
dgkA (mhcK, DDB_G0277223)
Protein name
Diacylglycerol kinase A
Names
Myosin heavy chain kinase, MHCK
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0277223
EC number
2.7.1.107: Phosphotransferases with an alcohol group as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

657-887 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34125

Entry ID Method Resolution Chain Position Source
AF-P34125-F1 Predicted AlphaFoldDB

No variants for P34125

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34125

No associated diseases with P34125

5 regional properties for P34125

Type Name Position InterPro Accession
domain Diacylglycerol kinase, accessory domain 484 - 657 IPR000756
domain Diacylglycerol kinase, catalytic domain 330 - 473 IPR001206
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 7 - 59 IPR002219-1
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 140 - 191 IPR002219-2
domain Protein kinase C-like, phorbol ester/diacylglycerol-binding domain 208 - 260 IPR002219-3

Functions

Description
EC Number 2.7.1.107 Phosphotransferases with an alcohol group as acceptor
Subcellular Localization
  • Membrane ; Peripheral membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

7 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
diacylglycerol binding Binding to a diacylglycerol, a diester of glycerol and two fatty acids.
diacylglycerol kinase activity Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol-3-phosphate.
metal ion binding Binding to a metal ion.
nucleotide binding Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
protein kinase activity Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.
protein serine/threonine kinase activity Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate.

10 GO annotations of biological process

Name Definition
anatomical structure morphogenesis The process in which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form.
cellular response to fatty acid Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fatty acid stimulus.
cellular response to lithium ion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus.
diacylglycerol metabolic process The chemical reactions and pathways involving diacylglycerol, a glyceride in which any two of the R groups (positions not specified) are acyl groups while the remaining R group can be either H or an alkyl group.
intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
lipid phosphorylation The process of introducing one or more phosphate groups into a lipid, any member of a group of substances soluble in lipid solvents but only sparingly soluble in aqueous solvents.
phosphatidic acid biosynthetic process The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids.
protein autophosphorylation The phosphorylation by a protein of one or more of its own amino acid residues (cis-autophosphorylation), or residues on an identical protein (trans-autophosphorylation).
protein kinase C-activating G protein-coupled receptor signaling pathway The series of molecular signals generated as a consequence of a G protein-coupled receptor binding to its physiological ligand, where the pathway proceeds with activation of protein kinase C (PKC). PKC is activated by second messengers including diacylglycerol (DAG).
regulation of positive chemotaxis Any process that modulates the frequency, rate or extent of the directed movement of a motile cell or organism towards a higher concentration in a concentration gradient of a specific chemical.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MNQLNISHNW KIKSFTSITF CDHCGSMLWG ICTQGFQCSD CNFSAHSHCT NLVTLHCNNN
70 80 90 100 110 120
KNNSKPNEKP ATITAAAASS STTTTTTTET STNTAASTTT TTNNIDIKNK DKTPTTSPFS
130 140 150 160 170 180
SPILSSYNNN SGNEFCSNRQ HKFHKTSKSI TKFCNYCRET TFTISGEPVM CSECRYIAHG
190 200 210 220 230 240
HCQTKVPLNC IIPYSSPINT INDGGNVRHH WVEGNLKKSK KCIHCMEPCE KSFSLAHYKC
250 260 270 280 290 300
LWCHKYLHSS CFDKHNPICD FGSLSDMILP PSSIRLLSTT ATTTNKIEKL IIEEQQPQLS
310 320 330 340 350 360
SSPSSPRLNI NNNNNNNEII EWELIENSNM PEKVLFVFVN SKSGGQFGST LIRKLSSLLN
370 380 390 400 410 420
PLQIIDLIKC GGPDSTLQMI NRYLAKHPEQ TNRFRILVCG GDGTVGWLFK QMTKHLVPST
430 440 450 460 470 480
IPIGIIPLGT GNDLARSLGW GIGYDGEKLI EILKSINEAK TIQMDTWSIE MWDDDKPEDR
490 500 510 520 530 540
RVIEMNNYFS IGLDAMVALG FHLARNANPQ LFTGRTVNKL WYTKIGLEEF VTKNFVSLAR
550 560 570 580 590 600
IVKINVGTRE IRVDRSIEGI IILNLGSYAG GVDLWGANRK DNQTHSDGTG NQFIDDQTLE
610 620 630 640 650 660
IVGVTSLPHL GSCLSSISSP IKMGQADEIR IQVSMPSIIL KDKSNEIETA FQVDGEPEPI
670 680 690 700 710 720
EVRNCTFKIS FFKKVSMLSN RSFKPRIENH DSDLSTFQIS QSPNLYSPPS FKNPPPNLNQ
730 740 750 760 770 780
YQQPHQPPQS QPQPQPQPQQ SLQSPQSPEP INNNTNNNNN NNNNNNNNNN NNNNNNNNNN
790 800 810 820 830 840
NNNNNNNNNN NNNNNNNSNN NNNNISNDLT NNSEVNPEKS TNNEKTNDNN NNNNNNINTP
850 860 870 880
FEPISLPDEN NNNNNNNNNN NNNNNNNNNN NETNSEKSYT NNCDEVD