P34088

PR
Gene name
RAG1
Protein name
V(D)J recombination-activating protein 1
Names
RAG-1
Species
Oryctolagus cuniculus (Rabbit)
KEGG Pathway
ocu:100328950
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

9-171 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34088

Entry ID Method Resolution Chain Position Source
AF-P34088-F1 Predicted AlphaFoldDB

No variants for P34088

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34088

No associated diseases with P34088

5 regional properties for P34088

Type Name Position InterPro Accession
domain Zinc finger, RING-type 292 - 331 IPR001841
conserved_site Zinc finger, RING-type, conserved site 307 - 316 IPR017907
domain V(D)J recombination-activating protein 1, Zinc finger 353 - 382 IPR019485
domain RAG nonamer-binding domain 391 - 458 IPR023336
domain RAG1 importin-binding 12 - 290 IPR035714

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.

8 GO annotations of molecular function

Name Definition
endonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks.
histone binding Binding to a histone, any of a group of water-soluble proteins found in association with the DNA of eukaryotic or archaeal chromosomes. They are involved in the condensation and coiling of chromosomes during cell division and have also been implicated in gene regulation and DNA replication. They may be chemically modified (methylated, acetlyated and others) to regulate gene transcription.
metal ion binding Binding to a metal ion.
protein homodimerization activity Binding to an identical protein to form a homodimer.
sequence-specific DNA binding Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding.
ubiquitin protein ligase activity Catalysis of the transfer of ubiquitin to a substrate protein via the reaction X-ubiquitin + S -> X + S-ubiquitin, where X is either an E2 or E3 enzyme, the X-ubiquitin linkage is a thioester bond, and the S-ubiquitin linkage is an amide bond: an isopeptide bond between the C-terminal glycine of ubiquitin and the epsilon-amino group of lysine residues in the substrate or, in the linear extension of ubiquitin chains, a peptide bond the between the C-terminal glycine and N-terminal methionine of ubiquitin residues.
ubiquitin-protein transferase activity Catalysis of the transfer of ubiquitin from one protein to another via the reaction X-Ub + Y --> Y-Ub + X, where both X-Ub and Y-Ub are covalent linkages.
zinc ion binding Binding to a zinc ion (Zn).

7 GO annotations of biological process

Name Definition
B cell differentiation The process in which a precursor cell type acquires the specialized features of a B cell. A B cell is a lymphocyte of B lineage with the phenotype CD19-positive and capable of B cell mediated immunity.
chromatin organization The assembly or remodeling of chromatin composed of DNA complexed with histones, other associated proteins, and sometimes RNA.
histone monoubiquitination The modification of histones by addition of a single ubiquitin group.
pre-B cell allelic exclusion Expression of a single heavy chain allele during pre-B cell differentiation.
protein autoubiquitination The ubiquitination by a protein of one or more of its own amino acid residues, or residues on an identical protein. Ubiquitination occurs on the lysine residue by formation of an isopeptide crosslink.
T cell differentiation in thymus The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.
V(D)J recombination The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAVSCTPTLG LSSAPDEIQH PHIKFSEWKF KLFRVRSFEK TTEENQKEKN SSEGKPSLEQ
70 80 90 100 110 120
SPAVLDKASG QKPEVAPPAF KVHPKFSKKF HDDGKARDKA IHQANLRHLC RICGNSLKTD
130 140 150 160 170 180
EHNRRYPVHG PVDSKTQGLL RKKEKKATSW PDLIAKVFRI DVKTDVDSIH PTEFCHNCWR
190 200 210 220 230 240
IMHRKFSGAP CEVYFPRNAT MEWHPHAPSC DICYTARRGL KRRNHQPNVQ LSKKLKTVLD
250 260 270 280 290 300
QARQARQRKR RVQARITSKE VMKMIANCSK IHLSTKLLAV DFPAHFVKSI SCQICEHILA
310 320 330 340 350 360
DPVETSCKHV FCRICILRCL KVMGSYCPSC QYPCFPTDLE SPVKSFLCIL NSLIVKCSAP
370 380 390 400 410 420
ECNEEVSLEK YNHHVSSHKE SRDTFVHINK GGRPRQHLLS LTRRAQKHRL RELKLQVKAF
430 440 450 460 470 480
ADKEEGGDVK SVCLTLFLLA LRARNEHRQA DELEAIMQGR GSGLQPAVCL AIRVNTFLSC
490 500 510 520 530 540
SQYHKMYRTV KAITGRQIFQ PLHALRNAEK VLLPGYHPFE WQPPLKNVSS STDVGIIDGL
550 560 570 580 590 600
SGLSSSVDDY PVDTIAKRFR YDSALVSALM DMEEDILEGM RSQDLEDYLN GPFTVVVKES
610 620 630 640 650 660
CDGMGDVTEK HGSGPAVPEK AVRFSFTVMK ITIAHGSQNV KVFEEAKPNS ELCCKPLCLM
670 680 690 700 710 720
LADESDHETL TAILSPLIAE REAMKSSELM LEMGGILRTF KFIFRGTGYD EKLVREVEGL
730 740 750 760 770 780
EASGSVYICT LCDATRLEAS QNLVFHSITR SHAENLERYE VWRSNPYHES VEELRDRVKG
790 800 810 820 830 840
VSAKPFIETV PSIDALHCDI GNAAEFYKIF QLEIGEVYKN PSASKEERKR WQATLDKHLR
850 860 870 880 890 900
KKMNLKPIMR MNGNFARKLM TIETVEAVCE LIPSKERHEA LRELMELYLK MKPVWRSSCP
910 920 930 940 950 960
AKECPESLCQ YSFNSQRFAE LLSTKFKYRY EGKITNYFHK TLAHVPEIIE RDGSIGAWAS
970 980 990 1000 1010 1020
EGNESGNKLF RRFRKMNARQ SKCYEMEDVL KHHWLYTSKY LQKFMNAHNA VKNSGFTMNS
1030 1040
QVSLEDPLGI EDSLESQYSM EF