P34046

PR
Gene name
gpaH (DDB_G0284469)
Protein name
Guanine nucleotide-binding protein alpha-8 subunit
Names
G alpha-8
Species
Dictyostelium discoideum (Slime mold)
KEGG Pathway
ddi:DDB_G0284469
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-53 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P34046

Entry ID Method Resolution Chain Position Source
AF-P34046-F1 Predicted AlphaFoldDB

No variants for P34046

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P34046

No associated diseases with P34046

No regional properties for P34046

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P34046

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
heterotrimeric G-protein complex Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G protein-coupled receptors to an effector protein.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

5 GO annotations of molecular function

Name Definition
G protein-coupled receptor binding Binding to a G protein-coupled receptor.
G-protein beta/gamma-subunit complex binding Binding to a complex of G-protein beta/gamma subunits.
GTP binding Binding to GTP, guanosine triphosphate.
GTPase activity Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
metal ion binding Binding to a metal ion.

7 GO annotations of biological process

Name Definition
adenylate cyclase-modulating G protein-coupled receptor signaling pathway A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP).
negative regulation of asexual reproduction Any process that stops, prevents or reduces the frequency, rate or extent of asexual reproduction.
positive regulation of cell-cell adhesion Any process that activates or increases the rate or extent of cell adhesion to another cell.
positive regulation of cell-substrate adhesion Any process that increases the frequency, rate or extent of cell-substrate adhesion. Cell-substrate adhesion is the attachment of a cell to the underlying substrate via adhesion molecules.
positive regulation of chemorepellent activity Any process that activates or increases the frequency, rate or extent of chemorepellent activity.
positive regulation of sporulation Any process that activates, maintains or increases the frequency, rate or extent of sporulation, the process whose specific outcome is the progression of a spore over time, from its initiation to the mature structure.
regulation of cell differentiation Any process that modulates the frequency, rate or extent of cell differentiation, the process in which relatively unspecialized cells acquire specialized structural and functional features.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGCYQSRVQV EDKTNEQLDK YLVQAGKEGL LDFRILLLGA GESGKSTVVK QLKSIYKIQV
70 80 90 100 110 120
DDDELHSYAV NIHKNTVLCM QVLLEAGETL GIELTDPETK KRAINVKSFQ FEPEVKQMPV
130 140 150 160 170 180
SIGLDIEELW RDEDIQKIWD RRSEYWFLDA TPYYFENIQR FLDDDFVPTE EDCIMTRVRT
190 200 210 220 230 240
TGISVTEFDE GPVHFRVVDV GGQRNERKKW IHCFDDVKAL LFVVNLAGYD QVMFEDPSQN
250 260 270 280 290 300
RMQESLTLFG QICNNPIFSE TPTFLVLNKK DLFEQMIQKT DLSKCFPDYK GGSDVKTALE
310 320 330 340 350 360
FIQMKYQQKI QESNKPLHTF HIAARYKKDI KYTWEEAKGI LLEENKKVLM KATKDLKKSS
370 380 390 400
KQSSKSSLGN STQNNSNNNN NNNNSNNNNG QTTIDGATAK INS