P33459

PR
Gene name
pol
Protein name
Pol polyprotein
Names
Species
Caprine arthritis encephalitis virus (strain Cork) (CAEV-Co)
KEGG Pathway
vg:1489976
EC number
3.1.13.2: Exoribonucleases producing 5'-phosphomonoesters
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

0 structures for P33459

Entry ID Method Resolution Chain Position Source

No variants for P33459

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P33459

No associated diseases with P33459

10 regional properties for P33459

Type Name Position InterPro Accession
domain Reverse transcriptase domain 191 - 380 IPR000477
domain Integrase, C-terminal, retroviral 1051 - 1103 IPR001037
domain Integrase, catalytic core 874 - 1034 IPR001584
active_site Aspartic peptidase, active site 65 - 76 IPR001969
domain Peptidase A2A, retrovirus, catalytic 63 - 134 IPR001995
domain Ribonuclease H domain 575 - 697 IPR002156
domain Integrase, N-terminal zinc-binding domain 832 - 873 IPR003308
domain Retropepsins 51 - 142 IPR018061
domain dUTPase-like 703 - 827 IPR029054
domain dUTPase, trimeric 712 - 799 IPR033704

Functions

Description
EC Number 3.1.13.2 Exoribonucleases producing 5'-phosphomonoesters
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

6 GO annotations of molecular function

Name Definition
aspartic-type endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile.
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
exoribonuclease H activity Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions.
RNA-directed DNA polymerase activity Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time.
RNA-DNA hybrid ribonuclease activity Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters.
zinc ion binding Binding to a zinc ion (Zn).

6 GO annotations of biological process

Name Definition
DNA integration The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
DNA recombination Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
establishment of integrated proviral latency A process by which the virus integrates into the host genome and establishes as a stable provirus or prophage.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
viral entry into host cell The process that occurs after viral attachment by which a virus, or viral nucleic acid, breaches the plasma membrane or cell envelope and enters the host cell. The process ends when the viral nucleic acid is released into the host cell cytoplasm.
viral genome integration into host DNA The insertion into a host genome of viral DNA, usually by the action of an integrase enzyme. Once integrated, the provirus persists in the host cell and serves as a template for the transcription of viral genes and replication of the viral genome, leading to the production of new viruses.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
TRNHMSQLWK ERTYAKRMQR KERHKGKTAG KREEGDTCGA VRSSYGITSA PPMVQVRIGS
70 80 90 100 110 120
QQRNLLFDTG ADRTIVRWHE GSGNPAGRIK LQGIGGIVEG EKWNNVELEY KGETRKGTIV
130 140 150 160 170 180
VLPQSPVEVL GRDNMARFGI KIIMANLEEK RIPITKVKLK EGCTGPHVPQ WPLTEEKLKG
190 200 210 220 230 240
LTEIIDKLVE EGKLGKAPPH WTCNTPIFCI KKKSGKWRML IDFRELNKQT EDLTEAQLGL
250 260 270 280 290 300
PHPGGLQKKK HVTILDIGDA YFTIPLYEPY REYTCFTLLS PNNLGPCKRY YWKVLPQGWK
310 320 330 340 350 360
LSPSVYQFTM QEILEDWIQQ HPEIQFGIYM DDIYIGSDLE IKKHREIVKD LANYIAQYGF
370 380 390 400 410 420
TLPEEKRQKG YPAKWLGFEL HPQTWKFQKH TLPELTKGTI TLNKLQKLVG ELVWRQSIIG
430 440 450 460 470 480
KSIPNILKLM EGDRELQSER KIEEVHVKEW EACRKKLEEM EGNYYNKDKD VYGQLAWGDK
490 500 510 520 530 540
AIEYIVYQEK GKPLWVNVVH NIKNLSIPQQ VIKAAQKLTQ EVIIRTGKIP WILLPGKEED
550 560 570 580 590 600
WRLELQLGNI TWMPKFWSCY RGHTRWRKRN IIEEVVEGPT YYTDGGKKNK VGSLGFIVST
610 620 630 640 650 660
GEKFRKHEEG TNQQLELRAI EEALKQGPQT MNLVTDSRYA FEFLLRNWDE EVIKNPIQAR
670 680 690 700 710 720
IMEIAHKKDR IGVHWVPGHK GIPQNEEIDK YISEIFLAKE GEGILPKREE DAGYDLICPE
730 740 750 760 770 780
EVTIEPGQVK CIPIELRLNL KKSQWAMIAT KSSMAAKGVF TQGGIIDSGY QGQIQVIMYN
790 800 810 820 830 840
SNKIAVVIPQ GRKFAQLILM DKKHGKLEPW GESRKTERGE KGFGSTGMYW IENIPLAEED
850 860 870 880 890 900
HTKWHQDARS LHLEFEIPRT AAEDIVNQCE ICKEARTPAV IRGGNKRGVN HWQVDYTHYE
910 920 930 940 950 960
NIILLVWVET NSGLIYAEKV KGESGQEFRI KVMHWYALFG PESLQSDNGP AFAAEPTQLL
970 980 990 1000 1010 1020
MQYLGVKHTT GIPWNPQSQA IVERAHQLLK STLKKFQPQF VAVESAIAAA LVAINIKRKG
1030 1040 1050 1060 1070 1080
GLGTSPMDIF IYNKEQKRIN NKYNKNSQKI QFCYYRIRKR GHQESGKDQP RYCGKGKEPI
1090 1100
VVKDIESEKY LVIPYKDAKF IPPPTKEKE