P33411

PR
Gene name
PRP18 (YGR006W)
Protein name
Pre-mRNA-splicing factor 18
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGR006W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-110 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P33411

Entry ID Method Resolution Chain Position Source
1DVK X-ray 215 A A/B 79-251 PDB
5MPS EM 385 A a 1-251 PDB
5MQ0 EM 417 A a 1-251 PDB
5WSG EM 400 A f 1-251 PDB
5YLZ EM 360 A U 1-251 PDB
6BK8 EM 330 A N 1-251 PDB
6EXN EM 370 A a 1-251 PDB
AF-P33411-F1 Predicted AlphaFoldDB

3 variants for P33411

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-506153 27 Q>R No SGRP
s07-506203 44 E>K No SGRP
s07-506264 64 S>N No SGRP

No associated diseases with P33411

1 regional properties for P33411

Type Name Position InterPro Accession
domain Prp18 132 - 244 IPR004098

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
U2-type post-spliceosomal complex A spliceosomal complex that is formed following the second splicing event and contains the spliced product, the excised intron, and three snRNPs, U5, U2 and U6.
U4/U6 x U5 tri-snRNP complex A ribonucleoprotein complex that is formed by the association of the U4/U6 and U5 snRNPs.
U5 snRNP A ribonucleoprotein complex that contains small nuclear RNA U5, a heptameric ring of Sm proteins, as well as several proteins that are unique to the U5 snRNP, most of which remain associated with the U5 snRNA both while the U5 snRNP is free or assembled into a series of spliceosomal complexes.

No GO annotations of molecular function

Name Definition
No GO annotations for molecular function

3 GO annotations of biological process

Name Definition
generation of catalytic spliceosome for second transesterification step Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing.
mRNA splicing, via spliceosome The joining together of exons from one or more primary transcripts of messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced.
nuclear mRNA surveillance A process that identifies and degrades defective or aberrant mRNAs within the nucleus.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDLDLASILK GEISKKKKEL ANSKGVQPPC TEKFQPHESA NIDETPRQVE QESTDEENLS
70 80 90 100 110 120
DNQSDDIRTT ISKLENRPER IQEAIAQDKT ISVIIDPSQI GSTEGKPLLS MKCNLYIHEI
130 140 150 160 170 180
LSRWKASLEA YHPELFLDTK KALFPLLLQL RRNQLAPDLL ISLATVLYHL QQPKEINLAV
190 200 210 220 230 240
QSYMKLSIGN VAWPIGVTSV GIHARSAHSK IQGGRNAANI MIDERTRLWI TSIKRLITFE
250
EWYTSNHDSL A