P33180
Gene name |
mepA (melA) |
Protein name |
Tyrosinase |
Names |
Monophenol monooxygenase |
Species |
Rhizobium meliloti (Ensifer meliloti) (Sinorhizobium meliloti) |
KEGG Pathway |
|
EC number |
1.14.18.1: With another compound as one donor, and incorporation of one atom of oxygen |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P33180
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P33180-F1 | Predicted | AlphaFoldDB |
No variants for P33180
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P33180 | |||||
No associated diseases with P33180
1 regional properties for P33180
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Tyrosinase copper-binding domain | 30 - 268 | IPR002227 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.14.18.1 | With another compound as one donor, and incorporation of one atom of oxygen |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| metal ion binding | Binding to a metal ion. |
| tyrosinase activity | Catalysis of the reaction: L-tyrosine + O2 = L-DOPAquinone + H2O. This reaction can use both monophenols (such as tyrosine) and catechols (o-diphenols) as substrates. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| melanin biosynthetic process | The chemical reactions and pathways resulting in the formation of melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MTSADGQKDL | QSYMDAVTAM | LKLPPSDRRN | WYRNGFIHLM | DCPHGDWWFT | SWHRGYLGYF |
| 70 | 80 | 90 | 100 | 110 | 120 |
| EETCRELSGN | PDFALPYWDW | TANPEVLPPL | FGTILDPVNS | SAYIPDHNRF | QDIMQEPIKA |
| 130 | 140 | 150 | 160 | 170 | 180 |
| YWDSLSPAQL | QQQNLRGYPD | FDALWSDAMA | SFANQPNARF | LTAQNPKLNP | ATQTAVDIDT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| IKASLAPTTF | ANDAGAPGLA | FNSPVSSSHQ | VAPVGFSILE | GQPHNRVHMS | VGGQSAPYGL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MSQNLSPLDP | IFFLHHCNID | RLWDVWTRKQ | QAMGLPVGPT | ADQQTQYDPE | PYLFYVNADG |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SPVSDKTRAA | DYLEIGDFDY | DYDPGSGEEV | IPVATAGRSA | PIPALEAAVS | ASAAVAINKP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ATAKLTVSQE | LVDVAAKPSE | QSRQFAKVSI | APPMDVGGLN | FLVFISPEGT | TPDLNPDGPD |
| 430 | 440 | 450 | 460 | 470 | 480 |
| FAGSFEFFGV | RHHHTDTVSF | TIPIDKALDR | LIDDGRLKAG | EPIDFAVVVA | QEGKRVEGSM |
| 490 | |||||
| PAKAQLTDIQ | VGSF |