P32964
Gene name |
cht |
Protein name |
Cyanide hydratase |
Names |
CHT, Cyanide-degrading nitrilase, Formamide hydrolyase |
Species |
Microdochium sorghi (Zonate leaf spot disease fungus) (Gloeocercospora sorghi) |
KEGG Pathway |
|
EC number |
4.2.1.66: Hydro-lyases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P32964
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P32964-F1 | Predicted | AlphaFoldDB |
No variants for P32964
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P32964 | |||||
No associated diseases with P32964
10 regional properties for P32964
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | UVR domain | 419 - 454 | IPR001943 |
| domain | AAA+ ATPase domain | 202 - 346 | IPR003593-1 |
| domain | AAA+ ATPase domain | 541 - 722 | IPR003593-2 |
| domain | ATPase, AAA-type, core | 207 - 319 | IPR003959-1 |
| domain | ATPase, AAA-type, core | 540 - 715 | IPR003959-2 |
| domain | Clp, repeat (R) domain | 2 - 144 | IPR004176 |
| conserved_site | ClpA/B, conserved site 1 | 297 - 309 | IPR018368 |
| domain | Clp ATPase, C-terminal | 721 - 811 | IPR019489 |
| conserved_site | ClpA/B, conserved site 2 | 575 - 593 | IPR028299 |
| domain | ClpA/ClpB, AAA lid domain | 345 - 445 | IPR041546 |
Functions
| Description | ||
|---|---|---|
| EC Number | 4.2.1.66 | Hydro-lyases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| cyanide hydratase activity | Catalysis of the reaction: formamide = H(2)O + hydrogen cyanide. |
| nitrilase activity | Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides. |
1 GO annotations of biological process
| Name | Definition |
|---|---|
| cyanide catabolic process | The chemical reactions and pathways resulting in the breakdown of cyanide, NC-, the anion of hydrocyanic acid. Cyanide is a potent inhibitor of respiration. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MPINKYKAAV | VTSEPVWENL | EGGVVKTIEF | INEAGKAGCK | LIAFPEVWIP | GYPYWMWKVN |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YLQSLPMLKA | YRENSIAMDS | SEMRRIRAAA | RDNQIYVSIG | VSEIDHATLY | LTQVLISPLG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DVINHRRKIK | PTHVEKLVYG | DGSGDSFEPV | TQTEIGRLGQ | LNCWENMNPF | LKSLAVARGE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| QIHVAAWPVY | PDLSKQVHPD | PATNYADPAS | DLVTPAYAIE | TGTWVLAPFQ | RISVEGLKRH |
| 250 | 260 | 270 | 280 | 290 | 300 |
| TPPGVEPETD | ATPYNGHARI | FRPDGSLYAK | PAVDFDGLMY | VDIDLNESHL | TKALADFAGH |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YMRPDLIRLL | VDTRRKELVT | EVGGGDNGGI | QSYSTMARLG | LDRPLEEEDY | RQGTDAGETE |
| KASSNGHA |