P32902

PR
Gene name
MRP4 (MRP4A, YHL004W)
Protein name
37S ribosomal protein MRP4, mitochondrial
Names
Mitochondrial small ribosomal subunit protein uS2m
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YHL004W
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

38-162 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P32902

Entry ID Method Resolution Chain Position Source
5MRC EM 325 A BB 128-393 PDB
5MRE EM 375 A BB 128-393 PDB
5MRF EM 497 A BB 128-393 PDB
8D8K EM 313 A B 1-394 PDB
8D8L EM 260 A B 1-394 PDB
8OM2 EM 257 A B 1-394 PDB
8OM3 EM 287 A B 1-394 PDB
8OM4 EM 232 A B 1-394 PDB
AF-P32902-F1 Predicted AlphaFoldDB

2 variants for P32902

Variant ID(s) Position Change Description Diseaes Association Provenance
s08-99522 103 L>S No SGRP
s08-99521 103 L>V No SGRP

No associated diseases with P32902

2 regional properties for P32902

Type Name Position InterPro Accession
conserved_site Ribosomal protein S2, conserved site 185 - 196 IPR018130-1
conserved_site Ribosomal protein S2, conserved site 317 - 341 IPR018130-2

Functions

Description
EC Number
Subcellular Localization
  • Mitochondrion
  • Mitoribosomes are tethered to the mitochondrial inner membrane and spatially aligned with the membrane insertion machinery through two distinct membrane contact sites, formed by the 21S rRNA expansion segment 96-ES1 and the inner membrane protein MBA1
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
mitochondrial inner membrane The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae.
mitochondrial small ribosomal subunit The smaller of the two subunits of a mitochondrial ribosome.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

1 GO annotations of molecular function

Name Definition
structural constituent of ribosome The action of a molecule that contributes to the structural integrity of the ribosome.

1 GO annotations of biological process

Name Definition
mitochondrial translation The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q9GCB9 RPS2 Ribosomal protein S2, mitochondrial Arabidopsis thaliana (Mouse-ear cress) PR
10 20 30 40 50 60
MQRHVFARNF RRLSLLRNPS LTKRFQSSAS GAANTPNNND EVMLLQQKLL YDEIRSELKS
70 80 90 100 110 120
LSQVPEDEIL PELKKSLEQD KLSDKEQQLE AELSDFFRNY ALLNKLFDSK TLDGQSSTTT
130 140 150 160 170 180
AAATPTKPYP NLIPSANDKP YSSQELFLRQ LNHSMRTAKL GATISKVYYP HKDIFYPPLP
190 200 210 220 230 240
ENITVESLMS AGVHLGQSTS LWRSSTQSYI YGEYKGIHII DLNQTLSYLK RAAKVVEGVS
250 260 270 280 290 300
ESGGIILFLG TRQGQKRGLE EAAKKTHGYY VSTRWIPGTL TNSTEISGIW EKQEIDSNDN
310 320 330 340 350 360
PTERALSPNE TSKQVKPDLL VVLNPTENRN ALLEAIKSRV PTIAIIDTDS EPSLVTYPIP
370 380 390
GNDDSLRSVN FLLGVLARAG QRGLQNRLAR NNEK