P32893
Gene name |
TRS65 (KRE11, YGR166W) |
Protein name |
Trafficking protein particle complex II-specific subunit 65 |
Names |
TRAPP II-specific subunit 65, Beta-glucan synthesis-associated protein TRS65, Killer toxin-resistance protein 11, Transport protein particle 65 kDa subunit |
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YGR166W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
10 structures for P32893
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 7E2C | EM | 418 A | K | 1-559 | PDB |
| 7E2D | EM | 371 A | K | 1-560 | PDB |
| 7E8S | EM | 436 A | K/V | 1-560 | PDB |
| 7E8T | EM | 380 A | K | 1-560 | PDB |
| 7E93 | EM | 654 A | K/V | 1-560 | PDB |
| 7E94 | EM | 467 A | K/V | 1-560 | PDB |
| 7EA3 | EM | 431 A | K/X | 1-560 | PDB |
| 7U05 | EM | 370 A | C/c | 1-560 | PDB |
| 7U06 | EM | 420 A | C/c | 1-560 | PDB |
| AF-P32893-F1 | Predicted | AlphaFoldDB |
16 variants for P32893
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s07-830681 | 54 | Q>H | No | SGRP | |
| s07-830695 | 59 | L>S | No | SGRP | |
| s07-830776 | 86 | R>K | No | SGRP | |
| s07-830898 | 127 | Q>E | No | SGRP | |
| s07-830926 | 136 | K>R | No | SGRP | |
| s07-830997 | 160 | A>T | No | SGRP | |
| s07-831018 | 167 | N>D | No | SGRP | |
| s07-831046 | 176 | N>S | No | SGRP | |
| s07-831135 | 206 | Q>K | No | SGRP | |
| s07-831412 | 298 | T>I | No | SGRP | |
| s07-831639 | 374 | V>F | No | SGRP | |
| s07-831703 | 395 | G>A | No | SGRP | |
| s07-831939 | 474 | G>W | No | SGRP | |
| s07-831992 | 491 | N>K | No | SGRP | |
| s07-832078 | 520 | A>V | No | SGRP | |
| s07-832156 | 546 | N>S | No | SGRP |
No associated diseases with P32893
No regional properties for P32893
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| No domain, repeats, and functional sites for P32893 | |||
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
| trans-Golgi network | The network of interconnected tubular and cisternal structures located within the Golgi apparatus on the side distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination. |
| TRAPPII protein complex | A complex that mediates intra-Golgi traffic, Golgi exit, endosome-to-Golgi traffic, and the trafficking of autophagy proteins from Golgi to the phagophore assembly site. Binds to a component of the COPI coat. In yeast it includes the following subunits: Bet3 (as homodimer), Bet5, Tca17, Trs20, Trs23, Trs31, Trs33, Trs65, Trs120, Trs130. The whole complex is thought to dimerize with itself. |
No GO annotations of molecular function
| Name | Definition |
|---|---|
| No GO annotations for molecular function |
6 GO annotations of biological process
| Name | Definition |
|---|---|
| beta-glucan biosynthetic process | The chemical reactions and pathways resulting in the formation of beta-glucans. |
| cell wall organization | A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. |
| intra-Golgi vesicle-mediated transport | The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network). |
| protein-containing complex assembly | The aggregation, arrangement and bonding together of a set of macromolecules to form a protein-containing complex. |
| regulation of catalytic activity | Any process that modulates the activity of an enzyme. |
| retrograde transport, endosome to Golgi | The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MECFVPLRCD | LDGSNIEQLR | QSHLSRKFII | FDEQLNLWLW | FQGNSQENKR | FVLQNMIILI |
| 70 | 80 | 90 | 100 | 110 | 120 |
| NEAQVTRTST | IDDYFTQVEN | NENLWRLKND | CCSKILFKSN | VVMNNGYNNQ | IKFVFEYKSV |
| 130 | 140 | 150 | 160 | 170 | 180 |
| DANFNNQDSL | QDPQAKYTLD | KYSSEEILPS | FEPVYSWSSA | ATKSSKNTNN | HLEKNNRATH |
| 190 | 200 | 210 | 220 | 230 | 240 |
| RVSSKNSEVH | EADVSRNPNT | FTLKLQYPIF | SLLNMRLRNI | SLKSEHCILS | SLDFQTSKAS |
| 250 | 260 | 270 | 280 | 290 | 300 |
| EQLTKKFIYP | QEHNSFLKLN | FQEISYKLID | GTSQIELDPI | CPLKVPLTAF | SYDSISATFK |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LVLLPKSTQP | HRVKITLAYE | LELHPNLKLP | VRTSWETEVT | LKRSMPISST | SSQYSSNNNN |
| 370 | 380 | 390 | 400 | 410 | 420 |
| TNHSASFNGA | ANNVNSGGLA | NLRLGGVSSS | RFSLGAASTT | SLVNSKLSNV | KFKFINSNIK |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VIKGEKFTMR | LQIINSSSSP | LDLVVYYNNT | INPIPSANNV | RNSNGINNCG | MNNGTIPNSP |
| 490 | 500 | 510 | 520 | 530 | 540 |
| LTLENQYQLH | NKYRKIAEGI | ILLSNDYKIP | VVPPRETYFA | DLRFIGIMSG | YYGTLSGLKV |
| 550 | |||||
| LDLNTNELIE | VGNGASVLIQ |