P32787
Gene name |
MGM101 (MGM9, YJR144W, J2181) |
Protein name |
Mitochondrial genome maintenance protein MGM101 |
Names |
|
Species |
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
KEGG Pathway |
sce:YJR144W |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P32787
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P32787-F1 | Predicted | AlphaFoldDB |
2 variants for P32787
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| s10-701235 | 120 | D>E | No | SGRP | |
| s10-701362 | 163 | R>* | No | SGRP |
No associated diseases with P32787
3 GO annotations of cellular component
| Name | Definition |
|---|---|
| mitochondrial chromosome | A chromosome found in the mitochondrion of a eukaryotic cell. |
| mitochondrial nucleoid | The region of a mitochondrion to which the DNA is confined. |
| mitochondrion | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| single-stranded DNA binding | Binding to single-stranded DNA. |
4 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA repair | The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. |
| interstrand cross-link repair | Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication. |
| mitochondrial genome maintenance | The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome. |
| recombinational repair | A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKSIFKVRGC | VSHAAQFCQK | RTVVSTGTSN | TATAGAVRKS | FNSTETKPVF | ATKSEAGNGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| HMKEYSSGIN | SKLGGTPLET | RSTADDSLNN | SYKQVKGDID | WYTSWYGLGM | KPFEAKVQKD |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIEPLDPKDI | EIKPDGLIYL | PEIKYRRILN | KAFGAGGWGL | VPRSQTIVTS | KLVTREYGLI |
| 190 | 200 | 210 | 220 | 230 | 240 |
| CHGQLISVAR | GEQDYFNEAG | IPTATEGCKS | NALMRCCKDL | GVGSELWDPV | FIKKFKVDHC |
| 250 | 260 | ||||
| TEKFVEHVTT | KRKKKIWLRK | DRQVEYPYK |