P32608

PR
Gene name
RTG2 (YGL252C, NRF588)
Protein name
Retrograde regulation protein 2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YGL252C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-44 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P32608

Entry ID Method Resolution Chain Position Source
AF-P32608-F1 Predicted AlphaFoldDB

4 variants for P32608

Variant ID(s) Position Change Description Diseaes Association Provenance
s07-26980 169 V>I No SGRP
s07-26777 236 D>E No SGRP
s07-26364 374 T>K No SGRP
s07-26122 455 S>T No SGRP

No associated diseases with P32608

1 regional properties for P32608

Type Name Position InterPro Accession
domain Ppx/GppA phosphatase 33 - 346 IPR003695

Functions

Description
EC Number
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
euchromatin A dispersed and relatively uncompacted form of chromatin that is in a transcription-competent conformation.

1 GO annotations of molecular function

Name Definition
phosphoprotein binding Binding to a phosphorylated protein.

7 GO annotations of biological process

Name Definition
maintenance of DNA trinucleotide repeats Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs.
mitochondria-nucleus signaling pathway The series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function.
nitrogen catabolite regulation of transcription from RNA polymerase II promoter A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription, from an RNA polymerase II promoter, of specific genes involved in the metabolism of other nitrogen sources.
positive regulation of transcription by RNA polymerase II Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter.
protein import into nucleus The directed movement of a protein from the cytoplasm to the nucleus.
protein localization to nucleus A process in which a protein transports or maintains the localization of another protein to the nucleus.
regulation of transcription by RNA polymerase II Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSTLSDSDTE TEVVSRNLCG IVDIGSNGIR FSISSKAAHH ARIMPCVFKD RVGLSLYEVQ
70 80 90 100 110 120
YNTHTNAKCP IPRDIIKEVC SAMKRFKLIC DDFGVPETSV RVIATEATRD AINADEFVNA
130 140 150 160 170 180
VYGSTGWKVE ILGQEDETRV GIYGVVSSFN TVRGLYLDVA GGSTQLSWVI SSHGEVKQSS
190 200 210 220 230 240
KPVSLPYGAG TLLRRMRTDD NRALFYEIKE AYKDAIEKIG IPQEMIDDAK KEGGFDLWTR
250 260 270 280 290 300
GGGLRGMGHL LLYQSEGYPI QTIINGYACT YEEFSSMSDY LFLKQKIPGS SKEHKIFKVS
310 320 330 340 350 360
DRRALQLPAV GLFMSAVFEA IPQIKAVHFS EGGVREGSLY SLLPKEIRAQ DPLLIASRPY
370 380 390 400 410 420
APLLTEKYLY LLRTSIPQED IPEIVNERIA PALCNLAFVH ASYPKELQPT AALHVATRGI
430 440 450 460 470 480
IAGCHGLSHR ARALIGIALC SRWGGNIPES EEKYSQELEQ VVLREGDKAE ALRIVWWTKY
490 500 510 520 530 540
IGTIMYVICG VHPGGNIRDN VFDFHVSKRS EVETSLKELI IDDANTTKVK EESTRKNRGY
550 560 570 580
EVVVRISKDD LKTSASVRSR IITLQKKVRK LSRGSVERVK IGVQFYEE