P32502

PR
Gene name
GCD7 (TIF222, YLR291C, L8003.17)
Protein name
Translation initiation factor eIF-2B subunit beta
Names
GCD complex subunit GCD7, Guanine nucleotide exchange factor subunit GCD7, eIF-2B GDP-GTP exchange factor subunit beta
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YLR291C
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

83-174 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

9 structures for P32502

Entry ID Method Resolution Chain Position Source
6I3M EM 393 A E/F 1-381 PDB
6I7T EM 461 A E/F 1-381 PDB
6QG0 EM 420 A C/D 1-381 PDB
6QG1 EM 420 A C/D 1-381 PDB
6QG2 EM 460 A C/D 1-381 PDB
6QG3 EM 940 A C/D 1-381 PDB
6QG5 EM 1010 A C/D 1-381 PDB
6QG6 EM 465 A C/D 1-381 PDB
AF-P32502-F1 Predicted AlphaFoldDB

1 variants for P32502

Variant ID(s) Position Change Description Diseaes Association Provenance
s12-719038 143 S>G No SGRP

No associated diseases with P32502

No regional properties for P32502

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P32502

Functions

Description
EC Number
Subcellular Localization
  • Cytoplasm, cytosol
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
eukaryotic translation initiation factor 2B complex A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon.
guanyl-nucleotide exchange factor complex A protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
enzyme regulator activity Binds to and modulates the activity of an enzyme.
translation initiation factor activity Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide.

3 GO annotations of biological process

Name Definition
positive regulation of GTPase activity Any process that activates or increases the activity of a GTPase.
regulation of translational initiation Any process that modulates the frequency, rate or extent of translational initiation.
translational initiation The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
Q5E9B4 EIF2B2 Translation initiation factor eIF-2B subunit beta Bos taurus (Bovine) PR
10 20 30 40 50 60
MSSQAFTSVH PNAATSDVNV TIDTFVAKLK RRQVQGSYAI ALETLQLLMR FISAARWNHV
70 80 90 100 110 120
NDLIEQIRDL GNSLEKAHPT AFSCGNVIRR ILAVLRDEVE EDTMSTTVTS TSVAEPLISS
130 140 150 160 170 180
MFNLLQKPEQ PHQNRKNSSG SSSMKTKTDY RQVAIQGIKD LIDEIKNIDE GIQQIAIDLI
190 200 210 220 230 240
HDHEILLTPT PDSKTVLKFL ITARERSNRT FTVLVTEGFP NNTKNAHEFA KKLAQHNIET
250 260 270 280 290 300
LVVPDSAVFA LMSRVGKVII GTKAVFVNGG TISSNSGVSS VCECAREFRT PVFAVAGLYK
310 320 330 340 350 360
LSPLYPFDVE KFVEFGGSQR ILPRMDPRKR LDTVNQITDY VPPENIDIYI TNVGGFNPSF
370 380
IYRIAWDNYK QIDVHLDKNK A