P32440
Gene name |
hmd |
Protein name |
5,10-methenyltetrahydromethanopterin hydrogenase |
Names |
H(2)-dependent methylene-H(4)MPT dehydrogenase, H(2)-forming N(5),N(10)-methylenetetrahydromethanopterin dehydrogenase, N(5),N(10)-methenyltetrahydromethanopterin hydrogenase |
Species |
Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) (Methanobacterium thermoautotrophicum) |
KEGG Pathway |
mmg:MTBMA_c15260 |
EC number |
1.12.98.2: With other, known, acceptors |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 structures for P32440
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| 4JJF | X-ray | 220 A | A/B | 1-344 | PDB |
| 4JJG | X-ray | 250 A | A/B | 1-344 | PDB |
| 5OK4 | X-ray | 129 A | A | 1-344 | PDB |
| 6GGU | X-ray | 260 A | A | 1-344 | PDB |
| AF-P32440-F1 | Predicted | AlphaFoldDB |
No variants for P32440
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P32440 | |||||
No associated diseases with P32440
1 regional properties for P32440
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | H2-forming N5,N10-methylenetetrahydromethanopterin dehydrogenase, C-terminal | 245 - 341 | IPR004889 |
Functions
| Description | ||
|---|---|---|
| EC Number | 1.12.98.2 | With other, known, acceptors |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
1 GO annotations of molecular function
| Name | Definition |
|---|---|
| N5,N10-methenyltetrahydromethanopterin hydrogenase activity | Catalysis of the reaction: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin + H(2) = 5,10-methylenetetrahydromethanopterin + H(+). |
2 GO annotations of biological process
| Name | Definition |
|---|---|
| methanogenesis, from carbon dioxide | The chemical reactions and pathways resulting in the formation of methane, a colorless, odorless, flammable gas with the formula CH4, from other compounds, including carbon dioxide (CO2). |
| one-carbon metabolic process | The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MKLAILGAGC | YRTHAASGIT | NFSRACEVAE | MVGKPEIAMT | HSTITMGAEL | KELAGVDEVV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VADPVFDNQF | TVIDDFAYED | VIEAHKEDPE | KIMPQIREKV | NEVAKELPKP | PEGAIHFTHP |
| 130 | 140 | 150 | 160 | 170 | 180 |
| EDLGFEITTD | DREAVADADF | IMTWFPKGDM | QPDIINKFID | DIKPGAIVTH | ACTIPTTKFY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| KIFEQKHGDL | VTKPETLNVT | SYHPGAVPEM | KGQVYIAEGY | ASEDAIETLF | ELGQKARGNA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| YRLPAELLGP | VCDMCSALTA | ITYAGILSYR | DSVTQVLGAP | ASFAQMMAKE | SLEQITALME |
| 310 | 320 | 330 | 340 | ||
| KVGIDKMEEN | LDPGALLGTA | DSMNFGASAE | ILPTVFEILE | KRKK |