P32390
Gene name |
act2 (SPAC630.03) |
Protein name |
Actin-related protein 3 |
Names |
Actin-like protein 3 |
Species |
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast) |
KEGG Pathway |
spo:SPAC630.03 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
5 variants for P32390
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| I_350787_G_C | 59 | G>A | No | Jeffares_SNPs | |
| I_351394_C_G | 230 | P>A | No | Jeffares_SNPs | |
| I_351511_G_A | 269 | A>T | No | Jeffares_SNPs | |
| I_351533_A_G | 276 | H>R | No | Jeffares_SNPs | |
| I_351628_C_T | 308 | P>S | No | Jeffares_SNPs |
No associated diseases with P32390
1 regional properties for P32390
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Actin/actin-like conserved site | 127 - 139 | IPR020902 |
6 GO annotations of cellular component
| Name | Definition |
|---|---|
| actin cortical patch | An endocytic patch that consists of an actin-containing structure found at the plasma membrane in cells; formed of networks of branched actin filaments that lie just beneath the plasma membrane and assemble, move, and disassemble rapidly. An example of this is the actin cortical patch found in Saccharomyces cerevisiae. |
| Arp2/3 protein complex | A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments. |
| cell cortex of cell tip | The region directly beneath the plasma membrane at the cell tip. The cell tip is the region at either end of the longest axis of a cylindrical or elongated cell. |
| cell division site | The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. |
| cytoplasm | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. |
| cytosol | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| actin filament binding | Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. |
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
5 GO annotations of biological process
| Name | Definition |
|---|---|
| actin cortical patch organization | A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane in cells, at sites of endocytosis. |
| actin filament polymerization | Assembly of actin filaments by the addition of actin monomers to a filament. |
| Arp2/3 complex-mediated actin nucleation | The actin nucleation process in which actin monomers combine to form a new branch on the side of an existing actin filament; mediated by the Arp2/3 protein complex and its interaction with other proteins. |
| endocytosis | A vesicle-mediated transport process in which cells take up external materials or membrane constituents by the invagination of a small region of the plasma membrane to form a new membrane-bounded vesicle. |
| mitotic cytokinesis | A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MASFNVPIIM | DNGTGYSKLG | YAGNDAPSYV | FPTVIATRSA | GASSGPAVSS | KPSYMASKGS |
| 70 | 80 | 90 | 100 | 110 | 120 |
| GHLSSKRATE | DLDFFIGNDA | LKKASAGYSL | DYPIRHGQIE | NWDHMERFWQ | QSLFKYLRCE |
| 130 | 140 | 150 | 160 | 170 | 180 |
| PEDHYFLLTE | PPLNPPENRE | NTAEIMFESF | NCAGLYIAVQ | AVLALAASWT | SSKVTDRSLT |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GTVVDSGDGV | THIIPVAEGY | VIGSSIKTMP | LAGRDVTYFV | QSLLRDRNEP | DSSLKTAERI |
| 250 | 260 | 270 | 280 | 290 | 300 |
| KEECCYVCPD | IVKEFSRFDR | EPDRYLKYAS | ESITGHSTTI | DVGFERFLAP | EIFFNPEIAS |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SDFLTPLPEL | VDNVVQSSPI | DVRKGLYKNI | VLSGGSTLFK | NFGNRLQRDL | KRIVDERIHR |
| 370 | 380 | 390 | 400 | 410 | 420 |
| SEMLSGAKSG | GVDVNVISHK | RQRNAVWFGG | SLLAQTPEFG | SYCHTKADYE | EYGASIARRY |
| QIFGNSL |