P32372

PR
Gene name
rad4 (cut5, SPAC23C4.18c)
Protein name
S-M checkpoint control protein rad4
Names
P74, Protein cut5
Species
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
KEGG Pathway
spo:SPAC23C4.18c
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

169-241 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

7 structures for P32372

Entry ID Method Resolution Chain Position Source
4BMC X-ray 198 A A 1-186 PDB
4BMD X-ray 250 A A 291-494 PDB
4BU0 X-ray 150 A A 1-186 PDB
4BU1 X-ray 210 A A/B 1-186 PDB
6HM3 X-ray 177 A A 1-186 PDB
6HM4 X-ray 177 A A 1-186 PDB
AF-P32372-F1 Predicted AlphaFoldDB

7 variants for P32372

Variant ID(s) Position Change Description Diseaes Association Provenance
I_1062513_G_T 76 P>T No Jeffares_SNPs
I_1062086_T_C 218 K>R No Jeffares_SNPs
I_1061875_G_C 288 N>K No Jeffares_SNPs
I_1061821_C_A 306 L>F No Jeffares_SNPs
I_1061795_T_C 315 N>S No Jeffares_SNPs
I_1061055_T_G 562 T>P No Jeffares_SNPs
I_1061015_T_C 575 K>R No Jeffares_SNPs

No associated diseases with P32372

4 regional properties for P32372

Type Name Position InterPro Accession
domain BRCT domain 2 - 82 IPR001357-1
domain BRCT domain 100 - 185 IPR001357-2
domain BRCT domain 298 - 384 IPR001357-3
domain BRCT domain 392 - 480 IPR001357-4

Functions

Description
EC Number
Subcellular Localization
  • Nucleus
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

8 GO annotations of cellular component

Name Definition
chromatin The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome.
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
DNA replication preinitiation complex A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.
mitotic spindle A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules.
mitotic spindle pole body The microtubule organizing center that forms as part of the mitotic cell cycle; functionally homologous to the animal cell centrosome.
nuclear replication fork The Y-shaped region of a nuclear replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes.
nucleus A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
site of double-strand break A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.

1 GO annotations of molecular function

Name Definition
signaling adaptor activity The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.

4 GO annotations of biological process

Name Definition
DNA replication initiation The process in which DNA-dependent DNA replication is started; this begins with the ATP dependent loading of an initiator complex onto the DNA, this is followed by DNA melting and helicase activity. In bacteria, the gene products that enable the helicase activity are loaded after the initial melting and in archaea and eukaryotes, the gene products that enable the helicase activity are inactive when they are loaded and subsequently activate.
mitotic DNA damage checkpoint signaling A signal transduction process involved in mitotic DNA damage checkpoint.
mitotic DNA replication checkpoint signaling A signal transduction process that contributes to a mitotic DNA replication checkpoint.
mitotic G2 DNA damage checkpoint signaling A mitotic cell cycle checkpoint that detects and negatively regulates progression through the G2/M transition of the cell cycle in response to DNA damage.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MGSSKPLKGF VICCTSIDLK QRTEISTKAT KLGAAYRSDF TKDVTHLIAG DFDTPKYKFA
70 80 90 100 110 120
AKSRPDIKIM SSEWIPVLYE SWVQGEDLDD GLLVDKHFLP TLFKCRVCLT NIGQPERSRI
130 140 150 160 170 180
ENYVLKHGGT FCPDLTRDVT HLIAGTSSGR KYEYALKWKI NVVCVEWLWQ SIQRNAVLEP
190 200 210 220 230 240
QYFQLDMPAE KIGLGAYVRL DPNTTEAKSY SENQKISKNK EKSGQSLAAL AEEADLEPVI
250 260 270 280 290 300
MKRGKKRDRS ILWEELNNGK FEFSSRSEEN SVLLDDFTPE TVQPLEENEL DTELNIENEA
310 320 330 340 350 360
KLFKNLTFYL YEFPNTKVSR LHKCLSDNGG QISEFLSSTI DFVVIPHYFP VDELPIFSFP
370 380 390 400 410 420
TVNEWWIERC LYYKKIFGID EHALAKPFFR PSLVPYFNGL SIHLTGFKGE ELSHLKKALT
430 440 450 460 470 480
ILGAVVHEFL GVQRSILLVN TNEPFSMKTR FKIQHATEWN VRVVGVAWLW NIIQSGKFID
490 500 510 520 530 540
QVSPWAIDKK ENQEIKKFTN QNNMVFPTSD RDTRLQNSLA QQPIGHSTPH NSPSLLSVKK
550 560 570 580 590 600
RQNNHIRSNT LIQLNSNSKD STIFPRRSVT VPGDKIDTVW KSSVTKPETP TSPQEHVSYI
610 620 630 640
DPDAQREKHK LYAQLTSNVD AIPPANDLQN QENGLLLITE SHRKLRRR