P32370

PR
Gene name
baiH
Protein name
7-beta-hydroxy-3-oxochol-24-oyl-CoA 4-desaturase
Names
NADH-dependent flavin oxidoreductase, NADH:flavin oxidoreductase, NADH:FOR
Species
Clostridium scindens (strain JCM 10418 / VPI 12708)
KEGG Pathway
ag:AAC45417
EC number
1.3.1.116: With NAD(+) or NADP(+) as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

88-159 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P32370

Entry ID Method Resolution Chain Position Source
AF-P32370-F1 Predicted AlphaFoldDB

No variants for P32370

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P32370

No associated diseases with P32370

2 regional properties for P32370

Type Name Position InterPro Accession
domain NADH:flavin oxidoreductase/NADH oxidase, N-terminal 8 - 337 IPR001155
domain FAD/NAD(P)-binding domain 384 - 625 IPR023753

Functions

Description
EC Number 1.3.1.116 With NAD(+) or NADP(+) as acceptor
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

No GO annotations of cellular component

Name Definition
No GO annotations for cellular component

4 GO annotations of molecular function

Name Definition
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
FMN binding Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.
metal ion binding Binding to a metal ion.
oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.

2 GO annotations of biological process

Name Definition
bile acid catabolic process The chemical reactions and pathways resulting in the breakdown of bile acids, any of a group of steroid carboxylic acids occurring in bile.
lipid catabolic process The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDMKHSRLFS PLQIGSLTLS NRVGMAPMSM DYEAADGTVP KRLADVFVRR AEGGTGYVMI
70 80 90 100 110 120
DAVTIDSKYP YMGNTTALDR DELVPQFKEF ADRVKEAGST LVPQIIHPGP ESVCGYRHIA
130 140 150 160 170 180
PLGPSANTNA NCHVSRSISI DEIHDIIKQF GQAARRAEEA GCGAISLHCA HAYMLPGSFL
190 200 210 220 230 240
SPLRNKRMDE YGGSLDNRAR FVIEMIEEAR RNVSPDFPIF LRISGDERMV GGNSLEDMLY
250 260 270 280 290 300
LAPKFEAAGV SMLEVSGGTQ YEGLEHIIPC QNKSRGVNVY EASEIKKVVG IPVYAVGKIN
310 320 330 340 350 360
DIRYAAEIVE RGLVDGVAMG RPLLADPDLC KKAVEGQFDE ITPCASCGGS CISRSEAAPE
370 380 390 400 410 420
CHCHINPRLG REYEFPDVPA EKSKKVLVIG AGPGGMMAAV TAAERGHDVT VWEADDKIGG
430 440 450 460 470 480
QLNLAVVAPG KQEMTQWMVH LNYRAKKAGV KFEFNKEATA EDVKALAPEA VIVATGAKPL
490 500 510 520 530 540
VPPIKGTQDY PVLTAHDFLR GKFVIPKGRV CVLGGGAVAC ETAETALENA RPNSYTRGYD
550 560 570 580 590 600
ASIGDIDVTL VEMLPQLLTG VCAPNREPLI RKLKSKGVHI NVNTKIMEVT DHEVKVQRQD
610 620 630 640 650 660
GTQEWLEGFD YVLFGLGSRN YDPLSETLKE FVPEVHVIGD AVRARQASYA MWEGFEKAYS
L