P32316

PR
Gene name
ACH1 (YBL015W, YBL03.18, YBL0304)
Protein name
Acetyl-CoA hydrolase
Names
Acetyl-CoA deacylase, Acetyl-CoA acylase
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YBL015W
EC number
3.1.2.1: Thiolester hydrolases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-43 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

2 structures for P32316

Entry ID Method Resolution Chain Position Source
8DH7 EM 299 A A/B 1-526 PDB
AF-P32316-F1 Predicted AlphaFoldDB

1 variants for P32316

Variant ID(s) Position Change Description Diseaes Association Provenance
s02-195701 526 D>G No SGRP

No associated diseases with P32316

2 regional properties for P32316

Type Name Position InterPro Accession
domain Acetyl-CoA hydrolase/transferase, N-terminal 12 - 230 IPR003702
domain Acetyl-CoA hydrolase/transferase C-terminal domain 331 - 481 IPR026888

Functions

Description
EC Number 3.1.2.1 Thiolester hydrolases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
mitochondrion A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration.

2 GO annotations of molecular function

Name Definition
acetate CoA-transferase activity Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA.
acetyl-CoA hydrolase activity Catalysis of the reaction: acetyl-CoA + H(2)O = acetate + CoA + H(+).

2 GO annotations of biological process

Name Definition
acetate metabolic process The chemical reactions and pathways involving acetate, the anion of acetic acid.
propionate metabolic process, methylcitrate cycle The chemical reactions and pathways involving propionate that occur in the methylcitrate cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTISNLLKQR VRYAPYLKKV KEAHELIPLF KNGQYLGWSG FTGVGTPKAV PEALIDHVEK
70 80 90 100 110 120
NNLQGKLRFN LFVGASAGPE ENRWAEHDMI IKRAPHQVGK PIAKAINQGR IEFFDKHLSM
130 140 150 160 170 180
FPQDLTYGFY TRERKDNKIL DYTIIEATAI KEDGSIVPGP SVGGSPEFIT VSDKVIIEVN
190 200 210 220 230 240
TATPSFEGIH DIDMPVNPPF RKPYPYLKVD DKCGVDSIPV DPEKVVAIVE STMRDQVPPN
250 260 270 280 290 300
TPSDDMSRAI AGHLVEFFRN EVKHGRLPEN LLPLQSGIGN IANAVIEGLA GAQFKHLTVW
310 320 330 340 350 360
TEVLQDSFLD LFENGSLDYA TATSVRLTEK GFDRAFANWE NFKHRLCLRS QVVSNNPEMI
370 380 390 400 410 420
RRLGVIAMNT PVEVDIYAHA NSTNVNGSRM LNGLGGSADF LRNAKLSIMH APSARPTKVD
430 440 450 460 470 480
PTGISTIVPM ASHVDQTEHD LDILVTDQGL ADLRGLSPKE RAREIINKCA HPDYQALLTD
490 500 510 520
YLDRAEHYAK KHNCLHEPHM LKNAFKFHTN LAEKGTMKVD SWEPVD