P31814

PR
Gene name
rpo2
Protein name
DNA-directed RNA polymerase subunit Rpo2
Names
DNA-directed RNA polymerase subunit B
Species
Thermococcus celer
KEGG Pathway
EC number
2.7.7.6: Nucleotidyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

411-480 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P31814

Entry ID Method Resolution Chain Position Source
AF-P31814-F1 Predicted AlphaFoldDB

No variants for P31814

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P31814

No associated diseases with P31814

10 regional properties for P31814

Type Name Position InterPro Accession
domain Aspartate/glutamate/uridylate kinase 92 - 374 IPR001048
domain Aspartate kinase 91 - 556 IPR001341
domain Homoserine dehydrogenase, catalytic 713 - 911 IPR001342
domain ACT domain 417 - 489 IPR002912-1
domain ACT domain 498 - 575 IPR002912-2
domain Aspartate/homoserine dehydrogenase, NAD-binding 569 - 705 IPR005106
conserved_site Aspartate kinase, conserved site 94 - 102 IPR018042
conserved_site Homoserine dehydrogenase, conserved site 759 - 781 IPR019811
domain CASTOR, ACT domain 491 - 554 IPR027795
domain Bifunctional aspartokinase/homoserine dehydrogenase, N-terminal catalytic domain 92 - 386 IPR041743

Functions

Description
EC Number 2.7.7.6 Nucleotidyltransferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
DNA-directed RNA polymerase complex A protein complex that possesses DNA-directed RNA polymerase activity.

4 GO annotations of molecular function

Name Definition
DNA binding Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
DNA-directed 5'-3' RNA polymerase activity Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'.
ribonucleoside binding Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.
zinc ion binding Binding to a zinc ion (Zn).

1 GO annotations of biological process

Name Definition
DNA-templated transcription The synthesis of an RNA transcript from a DNA template.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MASRGPTVVD VTPDDLWLVM EAYWKEKGLV RQHLDSYNAF IDHGMQEVID EFGGVKPDIP
70 80 90 100 110 120
DFEVKFGKVR LGEPEFQEAQ GQRKPLYPMD ARIRNLTYSA PIYLELIPVV NGVSQEAVEV
130 140 150 160 170 180
RIGELPIMLK SKACRLYGLS DEELIKLGED PKDPGGYFIV NGSERVIVSI EDLAPNKTLV
190 200 210 220 230 240
ERDERQNRII AKCFSYRHGY RALITVERRK DGILYVKLPN VPRPVKFVYV MRALGLLSDR
250 260 270 280 290 300
EIVEAVSDDP RIQHVLFDNL EDASDVTTQE EALDYIGKLS LPGQPKEYRL RRAQNIIDNN
310 320 330 340 350 360
LLPHMGVEEK DRKAKAYYLG MMALRVLELS LGLRGEDDKD HYANKRLKLA GDLLMDLFRV
370 380 390 400 410 420
AFGQLVKDMQ YQMTKTYQRK GERYTFENIQ RFVRNSIRPD VLSERIEHAL ATGSWPGGRT
430 440 450 460 470 480
GVSQLLDRTN YISTLSHLRR VTSPLSREQP HFEARDLHGT HWGRICPTET PEGPNCGLVK
490 500 510 520 530 540
NLALMSQITT GVPEEEVREY LERLGVVPIE ERRPNPDLWR LYLNGVLVGT VEDGEGFVNR
550 560 570 580 590 600
IRTDRRSGKI SDIINVALYQ DEDVKEIYVN SDDGRVRRPL IIVENGRPKL TREHVEAIKN
610 620 630 640 650 660
GSLTWSDLVK MGVIEYLDAE EEENALVATW PWEVTEEHTH LELMPAAILG IPASLVPYPE
670 680 690 700 710 720
HNARPRNTYG AGMAKQSLGL GWANFRIRVD TRGHLMHYPQ VPLVNSRIMK AVGFEERPAG
730 740 750 760 770 780
QNFVVAVLSY AGYNMEDAII MNKASIERGL ARSTFFRTYE AEEKRYLGGQ TDRFEIPDPT
790 800 810 820 830 840
IQGYLGERYY RHLDEDGIIF PESKVNGKDV LVGRTSPPRF LEEQSGLGGI ILQERRETSL
850 860 870 880 890 900
TVRPSETGVV DKVIITETGD GTKLVKVTTR DLRIPEFGDK FASRHGQKGV IGLIVPQEDM
910 920 930 940 950 960
PWTESGIVPD LIVNPHGIPS RMTVGQLIEA IGGKVASLKG RRVDGTAFIG EPEEKLRKEL
970 980 990 1000 1010 1020
EELGFKHSGR EVMYDGITGR RLEADVFVGV IYYQRLHHMV ADKMHARSRG PVQVLTKQPT
1030 1040 1050 1060 1070 1080
EGRAREGGLR FGEMERDVLI GHGAAMLLIE RLLEESDKTE VWVCENCGHI ALEDKRRGKV
1090 1100 1110 1120
YCPVCGEEER ISKVEMSYAF KLLLDELKAM GIRPSLKLVD RV