P31743

PR
Gene name
exeF
Protein name
Type II secretion system protein F
Names
T2SS protein F, General secretion pathway protein F
Species
Aeromonas hydrophila
KEGG Pathway
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-73 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P31743

Entry ID Method Resolution Chain Position Source
AF-P31743-F1 Predicted AlphaFoldDB

No variants for P31743

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P31743

No associated diseases with P31743

3 regional properties for P31743

Type Name Position InterPro Accession
conserved_site T2SS_GspF/T4SS_PilC conserved site 148 - 176 IPR001992
domain Type II secretion system protein GspF domain 54 - 176 IPR018076-1
domain Type II secretion system protein GspF domain 256 - 377 IPR018076-2

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
type II protein secretion system complex A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.

1 GO annotations of molecular function

Name Definition
metal ion binding Binding to a metal ion.

1 GO annotations of biological process

Name Definition
protein secretion by the type II secretion system The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MTEGDSARQV RQQLREQGLT PLEVNETTEK AKREANRFVL FRRGASTSEL ALITRQLATL
70 80 90 100 110 120
VGAGLTIEEA LRAVAEQCEK AHLRSLVATV RSKVVEGYSL ADSLGAFPHV FDQLFRSMVA
130 140 150 160 170 180
AGEKSGHLEK VLNRLADYTE QRQHMRTKLL QAMIYPIVLT LVAVGVISIL LTAVVPKVVA
190 200 210 220 230 240
QFEHMGQQLP ATTRFLIGTS ELMQHYGLWF LLLLFIGGFV WRWWLTDEKR RRHWHQVVLR
250 260 270 280 290 300
LPVIGRVSRG LNTARFARTL SILNASAVPL LEGMKIAGEV LSNDFARTRI GEATERVREG
310 320 330 340 350 360
TSLRKALDET KIFPPMMLHM IASGEQSGEL DSMLERAADN QDREFETQVN IALGVFEPLL
370 380
VVSMAGVVLF IVMSILQPIL ELNNMVNL