P31742

PR
Gene name
xpsE (pefE, XCC0660)
Protein name
Type II secretion system protein E
Names
T2SS protein E, General secretion pathway protein E, Type II traffic warden ATPase
Species
Xanthomonas campestris pv. campestris (strain ATCC 33913 / DSM 3586 / NCPPB 528 / LMG 568 / P 25)
KEGG Pathway
xcc:XCC0660
EC number
7.4.2.8: Linked to the hydrolysis of a nucleoside triphosphate
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

128-207 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

3 structures for P31742

Entry ID Method Resolution Chain Position Source
2D27 X-ray 221 A A 1-149 PDB
2D28 X-ray 200 A C 1-149 PDB
AF-P31742-F1 Predicted AlphaFoldDB

No variants for P31742

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P31742

No associated diseases with P31742

3 regional properties for P31742

Type Name Position InterPro Accession
domain Type II/IV secretion system domain 190 - 456 IPR001482
domain AAA+ ATPase domain 317 - 438 IPR003593
domain Type II secretion system protein GspE, N-terminal 45 - 152 IPR007831

Functions

Description
EC Number 7.4.2.8 Linked to the hydrolysis of a nucleoside triphosphate
Subcellular Localization
  • Cell inner membrane
  • Membrane association is not an intrinsic property but requires the XpsL/GspL gene product
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
type II protein secretion system complex A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex.

3 GO annotations of molecular function

Name Definition
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
identical protein binding Binding to an identical protein or proteins.
protein-exporting ATPase activity Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + protein+(in) -> ADP + phosphate + protein+(out); drives the concomitant secretion of proteins.

1 GO annotations of biological process

Name Definition
protein secretion by the type II secretion system The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MEQRSAETRI VEALLERRRL KDTDLVRARQ LQAESGMGLL ALLGRLGLVS ERDHAETCAE
70 80 90 100 110 120
VLGLPLVDAR QLGDTPPEML PEVQGLSLRF LKQFHLCPVG ERDGRLDLWI ADPYDDYAID
130 140 150 160 170 180
AVRLATGLPL LLQVGLRSEI DDLIERWYGQ GRSAMGTIVE TADGDASSTD DIEALRDLAS
190 200 210 220 230 240
EAPVIRLVNL VIQHAVELRA SDIHIEPFES RLKVRYRVDG VLVEGESPPA KLTAAVISRI
250 260 270 280 290 300
KIMAKLNIAE RRLPQDGRIM LRVQGKELDL RVSTVPTAHG ESVVMRLLDR ETVVFDFYKL
310 320 330 340 350 360
GFTEDFLPQF RKVLEQPHGI MLVTGPTGSG KTTTLYTALS QLNTSDVKII TVEDPVEYQI
370 380 390 400 410 420
EGINQIQAKP QIGLDFANAL RSIVRQDPDI IMIGEMRDLE TARIAIQSAL TGHLVLSTLH
430 440 450 460 470 480
TNNAAGGITR LLDMGVEDYL LTSTINGILA QRLVRKLDLA NAERYAASPE EIERFDLRRL
490 500 510 520 530 540
QPDGEIFLYR PRATAAAPTG YLGRTTIVEF LVMNDELRRA VMRRAGMGEI EQLARKSGMR
550 560
TMYEDGLSKA LRGETTIEEV LRVTEDA