P31572

PR
Gene name
caiB
Protein name
L-carnitine CoA-transferase
Names
Crotonobetainyl-CoA:carnitine CoA-transferase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0038
EC number
2.8.3.21: CoA-transferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

305-398 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

8 structures for P31572

Entry ID Method Resolution Chain Position Source
1XA3 X-ray 185 A A/B 2-405 PDB
1XA4 X-ray 190 A A/B 2-405 PDB
1XK6 X-ray 185 A A/B/C/D 1-405 PDB
1XK7 X-ray 160 A A/B/C 1-405 PDB
1XVT X-ray 230 A A 1-405 PDB
1XVU X-ray 240 A A 1-405 PDB
1XVV X-ray 240 A A 1-405 PDB
AF-P31572-F1 Predicted AlphaFoldDB

2 variants for P31572

Variant ID(s) Position Change Description Diseaes Association Provenance
187 V>A strain: O44:K74 [UniProt] No
302 T>A strain: O44:K74 [UniProt] No

No associated diseases with P31572

No regional properties for P31572

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P31572

Functions

Description
EC Number 2.8.3.21 CoA-transferases
Subcellular Localization
  • Cytoplasm
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.

1 GO annotations of molecular function

Name Definition
L-carnitine CoA-transferase activity Catalysis of the reactions: (E)-4-(trimethylammonio)but-2-enoyl-CoA + L-carnitine = (E)-4-(trimethylammonio)but-2-enoate + L-carnitinyl-CoA and 4-trimethylammoniobutanoyl-CoA + L-carnitine = 4-trimethylammoniobutanoate + L-carnitinyl-CoA.

1 GO annotations of biological process

Name Definition
carnitine catabolic process The chemical reactions and pathways resulting in the breakdown of carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MDHLPMPKFG PLAGLRVVFS GIEIAGPFAG QMFAEWGAEV IWIENVAWAD TIRVQPNYPQ
70 80 90 100 110 120
LSRRNLHALS LNIFKDEGRE AFLKLMETTD IFIEASKGPA FARRGITDEV LWQHNPKLVI
130 140 150 160 170 180
AHLSGFGQYG TEEYTNLPAY NTIAQAFSGY LIQNGDVDQP MPAFPYTADY FSGLTATTAA
190 200 210 220 230 240
LAALHKVRET GKGESIDIAM YEVMLRMGQY FMMDYFNGGE MCPRMSKGKD PYYAGCGLYK
250 260 270 280 290 300
CADGYIVMEL VGITQIEECF KDIGLAHLLG TPEIPEGTQL IHRIECPYGP LVEEKLDAWL
310 320 330 340 350 360
ATHTIAEVKE RFAELNIACA KVLTVPELES NPQYVARESI TQWQTMDGRT CKGPNIMPKF
370 380 390 400
KNNPGQIWRG MPSHGMDTAA ILKNIGYSEN DIQELVSKGL AKVED