Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P31389
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P31389-F1 | Predicted | AlphaFoldDB |
No variants for P31389
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P31389 | |||||
No associated diseases with P31389
1 regional properties for P31389
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 53 - 469 | IPR017452 |
1 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of plasma membrane | The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| calcium ion transmembrane transporter activity | Enables the transfer of calcium (Ca) ions from one side of a membrane to the other. |
| histamine receptor activity | Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans. |
10 GO annotations of biological process
| Name | Definition |
|---|---|
| calcium ion import | The directed movement of calcium ions into a cell or organelle. |
| cellular response to histamine | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a histamine stimulus. Histamine, the biogenic amine 2-(1H-imidazol-4-yl)ethanamine, is involved in local immune responses as well as regulating physiological function in the gut and acting as a neurotransmitter. |
| eosinophil chemotaxis | The movement of an eosinophil in response to an external stimulus. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| inositol phosphate-mediated signaling | A intracellular signal transduction in which the signal is transmitted within the cell via an inositol phosphate. Includes production of the inositol phosphate, and downstream effectors that further transmit the signal within the cell. Inositol phosphates are a group of mono- to poly-phosphorylated inositols, and include inositol monophosphate (IP), inositol trisphosphate (IP3), inositol pentakisphosphate (IP5) and inositol hexaphosphate (IP6). |
| manganese ion transmembrane transport | A process in which a manganese ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| positive regulation of inositol trisphosphate biosynthetic process | Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate. |
| positive regulation of vasoconstriction | Any process that activates or increases the frequency, rate or extent of vasoconstriction. |
| regulation of vascular permeability | Any process that modulates the extent to which blood vessels can be pervaded by fluid. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MSFLPGMTPV | TLSNFSWALE | DRMLEGNSTT | TPTRQLMPLV | VVLSSVSLVT | VALNLLVLYA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| VRSERKLHTV | GNLYIVSLSV | ADLIVGAVVM | PMSILYLHRS | AWILGRPLCL | FWLSMDYVAS |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TASIFSVFIL | CIDRYRSVQQ | PLRYLRYRTK | TRASATILGA | WLLSFLWVIP | ILGWHHFMAP |
| 190 | 200 | 210 | 220 | 230 | 240 |
| TSEPREKKCE | TDFYDVTWFK | VMTAIINFYL | PTLLMLWFYI | RIYKAVRRHC | QHRQLINSSL |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PSFSEMKLKL | ENAKVDTRRM | GKESPWEDPK | RCSKDASGVH | TPMPSSQHLV | DMPCAAVLSE |
| 310 | 320 | 330 | 340 | 350 | 360 |
| DEGGEVGTRQ | MPMLAVGDGR | CCEALNHMHS | QLELSGQSRA | THSISARPEE | WTVVDGQSFP |
| 370 | 380 | 390 | 400 | 410 | 420 |
| ITDSDTSTEA | APMGGQPRSG | SNSGLDYIKF | TWRRLRSHSR | QYTSGLHLNR | ERKAAKQLGC |
| 430 | 440 | 450 | 460 | 470 | 480 |
| IMAAFILCWI | PYFVFFMVIA | FCKSCSNEPV | HMFTIWLGYL | NSTLNPLIYP | LCNENFRKTF |
| KRILRIPP |