P31382

PR
Gene name
PMT2
Protein name
Dolichyl-phosphate-mannose--protein mannosyltransferase 2
Names
Species
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
KEGG Pathway
sce:YAL023C
EC number
2.4.1.109: Hexosyltransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-91 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

5 structures for P31382

Entry ID Method Resolution Chain Position Source
6P25 EM 320 A B 1-759 PDB
6P28 X-ray 135 A A 337-532 PDB
6P2R EM 320 A B 1-759 PDB
6ZQP X-ray 160 A A 339-533 PDB
AF-P31382-F1 Predicted AlphaFoldDB

4 variants for P31382

Variant ID(s) Position Change Description Diseaes Association Provenance
s01-108458 32 S>N No SGRP
s01-108392 54 A>V No SGRP
s01-107246 436 V>G No SGRP
s01-107088 489 G>S No SGRP

No associated diseases with P31382

3 regional properties for P31382

Type Name Position InterPro Accession
domain Glycosyl transferase family 39/83 69 - 312 IPR003342
domain MIR motif 339 - 529 IPR016093
domain Protein O-mannosyl-transferase, C-terminal four TM domain 548 - 751 IPR032421

Functions

Description
EC Number 2.4.1.109 Hexosyltransferases
Subcellular Localization
  • Endoplasmic reticulum membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

5 GO annotations of cellular component

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p.
dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
endoplasmic reticulum membrane The lipid bilayer surrounding the endoplasmic reticulum.
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
dolichyl-phosphate-mannose-protein mannosyltransferase activity Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein.

6 GO annotations of biological process

Name Definition
ER-associated misfolded protein catabolic process The chemical reactions and pathways resulting in the breakdown of misfolded proteins transported from the endoplasmic reticulum and targeted to cytoplasmic proteasomes for degradation.
fungal-type cell wall biogenesis A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a fungal-type cell wall. The fungal-type cell wall contains beta-glucan and may contain chitin.
protein exit from endoplasmic reticulum The directed movement of proteins from the endoplasmic reticulum.
protein O-linked glycosylation A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan.
protein O-linked mannosylation The transfer of mannose from dolichyl activated mannose to the hydroxyl group of a seryl or threonyl residue of a protein acceptor molecule, to form an O-linked protein-sugar linkage.
regulation of endoplasmic reticulum unfolded protein response Any process that modulates the frequency, rate or extent of endoplasmic reticulum unfolded protein response.

3 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P47190 PMT3 Dolichyl-phosphate-mannose--protein mannosyltransferase 3 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
P46971 PMT4 Dolichyl-phosphate-mannose--protein mannosyltransferase 4 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) PR
Q9UKY4 POMT2 Protein O-mannosyl-transferase 2 Homo sapiens (Human) PR
10 20 30 40 50 60
MSSSSSTGYS KNNAAHIKQE NTLRQRESSS ISVSEELSSA DERDAEDFSK EKPAAQSSLL
70 80 90 100 110 120
RLESVVMPVI FTALALFTRM YKIGINNHVV WDEAHFGKFG SYYLRHEFYH DVHPPLGKML
130 140 150 160 170 180
VGLSGYLAGY NGSWDFPSGE IYPDYLDYVK MRLFNASFSA LCVPLAYFTA KAIGFSLPTV
190 200 210 220 230 240
WLMTVLVLFE NSYSTLGRFI LLDSMLLFFT VASFFSFVMF HNQRSKPFSR KWWKWLLITG
250 260 270 280 290 300
ISLGCTISVK MVGLFIITMV GIYTVIDLWT FLADKSMSWK TYINHWLARI FGLIIVPFCI
310 320 330 340 350 360
FLLCFKIHFD LLSHSGTGDA NMPSLFQARL VGSDVGQGPR DIALGSSVVS IKNQALGGSL
370 380 390 400 410 420
LHSHIQTYPD GSNQQQVTCY GYKDANNEWF FNRERGLPSW SENETDIEYL KPGTSYRLVH
430 440 450 460 470 480
KSTGRNLHTH PVAAPVSKTQ WEVSGYGDNV VGDNKDNWVI EIMDQRGDED PEKLHTLTTS
490 500 510 520 530 540
FRIKNLEMGC YLAQTGNSLP EWGFRQQEVV CMKNPFKRDK RTWWNIETHE NERLPPRPED
550 560 570 580 590 600
FQYPKTNFLK DFIHLNLAMM ATNNALVPDP DKFDYLASSA WQWPTLNVGL RLCGWGDDNP
610 620 630 640 650 660
KYFLLGTPAS TWASSVAVLA FMATVVILLI RWQRQYVDLR NPSNWNVFLM GGFYPLLAWG
670 680 690 700 710 720
LHYMPFVIMS RVTYVHHYLP ALYFALIILA YCFDAGLQKW SRSKCGRIMR FVLYAGFMAL
730 740 750
VIGCFWYFSP ISFGMEGPSS NFRYLNWFST WDIADKQEA