P31286
Gene name |
wnt5a |
Protein name |
Protein Wnt-5a |
Names |
XWnt-5a |
Species |
Xenopus laevis (African clawed frog) |
KEGG Pathway |
xla:378689 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P31286
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P31286-F1 | Predicted | AlphaFoldDB |
No variants for P31286
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P31286 | |||||
No associated diseases with P31286
1 regional properties for P31286
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| conserved_site | Wnt protein, conserved site | 238 - 247 | IPR018161 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| extracellular region | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. |
| protein-containing complex | A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. |
2 GO annotations of molecular function
| Name | Definition |
|---|---|
| frizzled binding | Binding to a frizzled (fz) receptor. |
| Wnt-protein binding | Binding to a Wnt-protein, a secreted growth factor involved in signaling. |
7 GO annotations of biological process
| Name | Definition |
|---|---|
| anterior/posterior axis specification, embryo | The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote. |
| canonical Wnt signaling pathway | The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes. |
| cell migration involved in gastrulation | The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression). |
| dorsal/ventral axis specification | The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism. |
| negative regulation of canonical Wnt signaling pathway | Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. |
| positive regulation of transcription by RNA polymerase II | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. |
| Spemann organizer formation | Formation of the specialized region on the dorsalmost side of the embryo that acts as the main signaling center establishing the vertebrate body plan. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MRKNLWTFQF | GGEASGLVGS | AMVSQHFVVL | LMSLYCLTQS | VVESSSWWSL | GMNPVQMPEV |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YIIGAQPLCS | QLSGLSQGQK | KLCQLYQDHM | QFIGDGAKTG | IKECQYQFRH | RRWNCSTVDN |
| 130 | 140 | 150 | 160 | 170 | 180 |
| TSVFGRVMQI | GSRETAFTYA | ISAAGVVNAV | SRACREGELS | TCGCSRAARP | KDLPRDWLWG |
| 190 | 200 | 210 | 220 | 230 | 240 |
| GCGDNLDYGY | RFAKEFVDAR | EREKIHQKGS | YESSRIMMNL | HNNEAGRRAV | STLADVACKC |
| 250 | 260 | 270 | 280 | 290 | 300 |
| HGVSGSCSLK | TCWLQLADFR | KVGDHLKEKY | DSAGAMKLNT | RGKLVQVNNK | FNSPTMNDLV |
| 310 | 320 | 330 | 340 | 350 | 360 |
| YIDPSPDYCV | HNESTGSLGT | QGRLCNKTSE | GMDGCELMCC | GRGYDQFKTV | QTERCHCKFH |
| 370 | |||||
| WCCYVKCKKC | TEVVDQFACK |