P31228

PR
Gene name
DDO
Protein name
D-aspartate oxidase
Names
DASOX, DDO
Species
Bos taurus (Bovine)
KEGG Pathway
bta:280763
EC number
1.4.3.1: With oxygen as acceptor
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

252-322 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P31228

Entry ID Method Resolution Chain Position Source
AF-P31228-F1 Predicted AlphaFoldDB

1 variants for P31228

Variant ID(s) Position Change Description Diseaes Association Provenance
228 V>I some molecules [UniProt] No

No associated diseases with P31228

2 regional properties for P31228

Type Name Position InterPro Accession
domain FAD dependent oxidoreductase 6 - 322 IPR006076
conserved_site D-amino acid oxidase, conserved site 300 - 318 IPR006181

Functions

Description
EC Number 1.4.3.1 With oxygen as acceptor
Subcellular Localization
  • Peroxisome matrix
  • Cytoplasm, cytosol
  • Active in the peroxisomal matrix
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
peroxisome A small organelle enclosed by a single membrane, and found in most eukaryotic cells. Contains peroxidases and other enzymes involved in a variety of metabolic processes including free radical detoxification, lipid catabolism and biosynthesis, and hydrogen peroxide metabolism.

2 GO annotations of molecular function

Name Definition
D-aspartate oxidase activity Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + hydrogen peroxide.
FAD binding Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes.

1 GO annotations of biological process

Name Definition
D-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of D-amino acids, the D-enantiomers of amino acids.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P14920 DAO D-amino-acid oxidase Homo sapiens (Human) PR
O35078 Dao D-amino-acid oxidase Rattus norvegicus (Rat) PR
10 20 30 40 50 60
MDTVRIAVVG AGVMGLSTAV CISKMVPGCS ITVISDKFTP ETTSDVAAGM LIPPTYPDTP
70 80 90 100 110 120
IQKQKQWFKE TFDHLFAIVN SAEAEDAGVI LVSGWQIFQS IPTEEVPYWA DVVLGFRKMT
130 140 150 160 170 180
KDELKKFPQH VFGHAFTTLK CEGPAYLPWL QKRVKGNGGL ILTRRIEDLW ELHPSFDIVV
190 200 210 220 230 240
NCSGLGSRQL AGDSKIFPVR GQVLKVQAPW VKHFIRDSSG LTYIYPGVSN VTLGGTRQKG
250 260 270 280 290 300
DWNLSPDAEI SKEILSRCCA LEPSLRGAYD LREKVGLRPT RPSVRLEKEL LAQDSRRLPV
310 320 330 340
VHHYGHGSGG IAMHWGTALE ATRLVNECVQ VLRTPAPKSK L