P31119

PR
Gene name
aas
Protein name
Bifunctional protein Aas
Names
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b2836
EC number
2.3.1.40: Transferring groups other than amino-acyl groups
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

134-208 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P31119

Entry ID Method Resolution Chain Position Source
AF-P31119-F1 Predicted AlphaFoldDB

No variants for P31119

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P31119

No associated diseases with P31119

3 regional properties for P31119

Type Name Position InterPro Accession
domain AMP-dependent synthetase/ligase domain 233 - 619 IPR000873
domain Phospholipid/glycerol acyltransferase 15 - 140 IPR002123
conserved_site AMP-binding, conserved site 370 - 381 IPR020845

Functions

Description
EC Number 2.3.1.40 Transferring groups other than amino-acyl groups
Subcellular Localization
  • Cell inner membrane; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

3 GO annotations of cellular component

Name Definition
integral component of membrane The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.
plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.

4 GO annotations of molecular function

Name Definition
acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity Catalysis of the reaction: acyl- + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine.
ATP binding Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
long-chain fatty acid [acyl-carrier-protein] ligase activity Catalysis of the reaction: ATP + an acid
long-chain fatty acid-CoA ligase activity +Catalysis of the reaction: ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a long-chain fatty acid is a fatty acid with a chain length between C13 and C22.

2 GO annotations of biological process

Name Definition
fatty acid metabolic process The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis.
phospholipid biosynthetic process The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester.

1 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
O60488 ACSL4 Long-chain-fatty-acid--CoA ligase 4 Homo sapiens (Human) PR
10 20 30 40 50 60
MLFSFFRNLC RVLYRVRVTG DTQALKGERV LITPNHVSFI DGILLGLFLP VRPVFAVYTS
70 80 90 100 110 120
ISQQWYMRWL KSFIDFVPLD PTQPMAIKHL VRLVEQGRPV VIFPEGRITT TGSLMKIYDG
130 140 150 160 170 180
AGFVAAKSGA TVIPVRIEGA ELTHFSRLKG LVKRRLFPQI TLHILPPTQV AMPDAPRARD
190 200 210 220 230 240
RRKIAGEMLH QIMMEARMAV RPRETLYESL LSAMYRFGAG KKCVEDVNFT PDSYRKLLTK
250 260 270 280 290 300
TLFVGRILEK YSVEGERIGL MLPNAGISAA VIFGAIARRR MPAMMNYTAG VKGLTSAITA
310 320 330 340 350 360
AEIKTIFTSR QFLDKGKLWH LPEQLTQVRW VYLEDLKADV TTADKVWIFA HLLMPRLAQV
370 380 390 400 410 420
KQQPEEEALI LFTSGSEGHP KGVVHSHKSI LANVEQIKTI ADFTTNDRFM SALPLFHSFG
430 440 450 460 470 480
LTVGLFTPLL TGAEVFLYPS PLHYRIVPEL VYDRSCTVLF GTSTFLGHYA RFANPYDFYR
490 500 510 520 530 540
LRYVVAGAEK LQESTKQLWQ DKFGLRILEG YGVTECAPVV SINVPMAAKP GTVGRILPGM
550 560 570 580 590 600
DARLLSVPGI EEGGRLQLKG PNIMNGYLRV EKPGVLEVPT AENVRGEMER GWYDTGDIVR
610 620 630 640 650 660
FDEQGFVQIQ GRAKRFAKIA GEMVSLEMVE QLALGVSPDK VHATAIKSDA SKGEALVLFT
670 680 690 700 710
TDNELTRDKL QQYAREHGVP ELAVPRDIRY LKQMPLLGSG KPDFVTLKSW VDEAEQHDE