P30919

PR
Gene name
Aga
Protein name
N(4)-(Beta-N-acetylglucosaminyl)-L-asparaginase
Names
Aspartylglucosaminidase, AGA, Glycosylasparaginase, N4-(N-acetyl-beta-glucosaminyl)-L-asparagine amidase
Species
Rattus norvegicus (Rat)
KEGG Pathway
rno:290923
EC number
3.5.1.26: In linear amides
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

132-277 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P30919

Entry ID Method Resolution Chain Position Source
AF-P30919-F1 Predicted AlphaFoldDB

No variants for P30919

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P30919

No associated diseases with P30919

No regional properties for P30919

Type Name Position InterPro Accession
No domain, repeats, and functional sites for P30919

Functions

Description
EC Number 3.5.1.26 In linear amides
Subcellular Localization
  • Lysosome
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

4 GO annotations of cellular component

Name Definition
cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
endoplasmic reticulum The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached).
extracellular space That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid.
lysosome A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions.

3 GO annotations of molecular function

Name Definition
N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H(2)O = N-acetyl-beta-D-glucosaminylamine + L-aspartate + H(+).
peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
protein self-association Binding to a domain within the same polypeptide.

2 GO annotations of biological process

Name Definition
protein deglycosylation The removal of sugar residues from a glycosylated protein.
proteolysis The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.

2 homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
P20933 AGA N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Homo sapiens (Human) PR
Q64191 Aga N(4)-(beta-N-acetylglucosaminyl)-L-asparaginase Mus musculus (Mouse) PR
10 20 30 40 50 60
MARKWNLPFL LLPLVLGIPL VRGSNPLPLV VNTWPFKNAT EAAWWTLVSG GSALDAVEKG
70 80 90 100 110 120
CAMCEKEQCG GTVGFGGSPD EVGETTLDAM IMDGTAMDVG AVGGLRRIKN AIGVARKVLE
130 140 150 160 170 180
HTTHTLLVGD SATKFAVSMG FTSEDLSTNT SRALHSDWLS RNCQPNYWRN VIPDPSKYCG
190 200 210 220 230 240
PYKPPDFLEQ NNRAHKEVDI HSHDTIGMVV IHKTGHTAAG TSTNGLKFKI PGRVGDSPIP
250 260 270 280 290 300
GAGAYADDMA GAAAATGDGD TLLRFLPSYQ AVEYMRGGDD PARACQKVIS RIQKYYPKFF
310 320 330 340
GAVICANVTG SYGAACNRLP TFTQFSFMVY NSLHNQAIEE KVDCM