P30878

PR
Gene name
melB
Protein name
Melibiose permease
Names
Melibiose carrier, Melibiose transporter, Melibiose/cation symporter, Na+ (Li+)/melibiose symporter, Thiomethylgalactoside permease II
Species
Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)
KEGG Pathway
stm:STM4299
EC number
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

175-249 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

4 structures for P30878

Entry ID Method Resolution Chain Position Source
4M64 X-ray 335 A A/B/C/D 1-476 PDB
7L16 X-ray 315 A A 2-476 PDB
7L17 X-ray 305 A A 2-476 PDB
AF-P30878-F1 Predicted AlphaFoldDB

No variants for P30878

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P30878

No associated diseases with P30878

2 regional properties for P30878

Type Name Position InterPro Accession
domain Sodium:galactoside symporter 8 - 450 IPR001927
conserved_site Sodium:galactoside symporter, conserved site 59 - 84 IPR018043

Functions

Description
EC Number
Subcellular Localization
  • Cell inner membrane ; Multi-pass membrane protein
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
integral component of plasma membrane The component of the plasma membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.

1 GO annotations of molecular function

Name Definition
symporter activity Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy.

3 GO annotations of biological process

Name Definition
carbohydrate transport The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y.
organic substance transport The directed movement of organic substances into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore. An organic substance is a molecular entity that contains carbon.
sodium ion transport The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MSISLTTKLS YGFGAFGKDF AIGIVYMYLM YYYTDVVGLS VGLVGTLFLV ARIWDAINDP
70 80 90 100 110 120
IMGWIVNATR SRWGKFKPWI LIGTLTNSLV LFLLFSAHLF EGTAQVVFVC VTYILWGMTY
130 140 150 160 170 180
TIMDIPFWSL VPTITLDKRE REQLVPFPRF FASLAGFVTA GITLPFVSYV GGADRGFGFQ
190 200 210 220 230 240
MFTLVLIAFF IASTIVTLRN VHEVYSSDNG VTAGRPHLTL KTIVGLIYKN DQLSCLLGMA
250 260 270 280 290 300
LAYNIASNII NGFAIYYFTY VIGDADLFPY YLSYAGAANL LTLIVFPRLV KMLSRRILWA
310 320 330 340 350 360
GASVMPVLSC AGLFAMALAD IHNAALIVAA GIFLNIGTAL FWVLQVIMVA DTVDYGEFKL
370 380 390 400 410 420
NIRCESIAYS VQTMVVKGGS AFAAFFIALV LGLIGYTPNV AQSAQTLQGM QFIMIVLPVL
430 440 450 460 470
FFMMTLVLYF RYYRLNGDML RKIQIHLLDK YRKTPPFVEQ PDSPAISVVA TSDVKA