P30749

PR
Gene name
moaE (chlA5, b0785, JW0768)
Protein name
Molybdopterin synthase catalytic subunit
Names
MPT synthase subunit 2, Molybdenum cofactor biosynthesis protein E, Molybdopterin-converting factor large subunit, Molybdopterin-converting factor subunit 2
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b0785
EC number
2.8.1.12: Sulfurtransferases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

101-150 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

6 structures for P30749

Entry ID Method Resolution Chain Position Source
1FM0 X-ray 145 A E 1-150 PDB
1FMA X-ray 158 A E 1-150 PDB
1NVI X-ray 190 A E 1-150 PDB
1NVJ X-ray 215 A A/B/C/D/E/F 1-140 PDB
3BII X-ray 250 A E 2-150 PDB
AF-P30749-F1 Predicted AlphaFoldDB

No variants for P30749

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P30749

No associated diseases with P30749

4 regional properties for P30749

Type Name Position InterPro Accession
conserved_site MoaA/NifB/PqqE, iron-sulphur binding, conserved site 20 - 31 IPR000385
domain Elp3/MiaA/NifB-like, radical SAM core domain 14 - 222 IPR006638
domain Radical SAM 8 - 234 IPR007197
domain Molybdenum cofactor biosynthesis protein A-like, twitch domain 186 - 321 IPR010505

Functions

Description
EC Number 2.8.1.12 Sulfurtransferases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

2 GO annotations of cellular component

Name Definition
cytosol The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
MPT synthase complex A heterodimeric protein complex which catalyses sulfur transfer from the sulfur carrier subunit of MPT synthase to precursor Z to synthesize MPT as part of molybdopterin cofactor (Moco) biosynthesis. In E. coli the subunits are MoaE and MoaD; in human, MOCS2B and MOCS2A. Moco biosynthesis and its constituent molecules are evolutionarily conserved.

1 GO annotations of molecular function

Name Definition
molybdopterin synthase activity Catalysis of the conversion of precursor Z to molybdopterin, the final step in molybdopterin biosynthesis.

1 GO annotations of biological process

Name Definition
Mo-molybdopterin cofactor biosynthetic process The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAETKIVVGP QPFSVGEEYP WLAERDEDGA VVTFTGKVRN HNLGDSVNAL TLEHYPGMTE
70 80 90 100 110 120
KALAEIVDEA RNRWPLGRVT VIHRIGELWP GDEIVFVGVT SAHRSSAFEA GQFIMDYLKT
130 140
RAPFWKREAT PEGDRWVEAR ESDQQAAKRW