Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30552
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30552-F1 | Predicted | AlphaFoldDB |
1 variants for P30552
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| rs852420892 | 325 | R>P | No | EVA |
No associated diseases with P30552
1 regional properties for P30552
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | GPCR, rhodopsin-like, 7TM | 71 - 396 | IPR017452 |
2 GO annotations of cellular component
| Name | Definition |
|---|---|
| integral component of membrane | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. |
| plasma membrane | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. |
5 GO annotations of molecular function
| Name | Definition |
|---|---|
| cholecystokinin receptor activity | Combining with cholecystokinin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. Cholecystokinin can act as a neuropeptide or as a gastrointestinal hormone. |
| G protein-coupled receptor activity | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. |
| gastrin receptor activity | Combining with gastrin and transmitting the signal across the membrane by activating an associated G-protein to initiate a change in cell activity. |
| peptide hormone binding | Binding to a peptide with hormonal activity in animals. |
| type B gastrin/cholecystokinin receptor binding | Binding to a type B gastrin/cholecystokinin receptor. |
8 GO annotations of biological process
| Name | Definition |
|---|---|
| digestive tract development | The process whose specific outcome is the progression of the digestive tract over time, from its formation to the mature structure. The digestive tract is the anatomical structure through which food passes and is processed. |
| G protein-coupled receptor signaling pathway | The series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. |
| gastric acid secretion | The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion. |
| gland development | The process whose specific outcome is the progression of a gland over time, from its formation to the mature structure. A gland is an organ specialised for secretion. |
| pH reduction | Any process that reduces the internal pH of an organism, part of an organism or a cell, measured by the concentration of the hydrogen ion. |
| phospholipase C-activating G protein-coupled receptor signaling pathway | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). |
| positive regulation of cell population proliferation | Any process that activates or increases the rate or extent of cell proliferation. |
| positive regulation of cytosolic calcium ion concentration | Any process that increases the concentration of calcium ions in the cytosol. |
| 10 | 20 | 30 | 40 | 50 | 60 |
| MELLKLNRSA | QGSGAGPGAS | LCRAGGALLN | SSGAGNLSCE | PPRLRGAGTR | ELELAIRVTL |
| 70 | 80 | 90 | 100 | 110 | 120 |
| YAVIFLMSVG | GNVLIIVVLG | LSRRLRTVTN | AFLLSLAVSD | LLLAVACMPF | TLLPNLMGTF |
| 130 | 140 | 150 | 160 | 170 | 180 |
| IFGTVVCKAV | SYLMGVSVSV | STLSLVAIAL | ERYSAICRPL | QARVWQTRSH | AARVIIATWM |
| 190 | 200 | 210 | 220 | 230 | 240 |
| LSGLLMVPYP | VYTAVQPAGG | ARALQCVHRW | PSARVRQTWS | VLLLLLLFFV | PGVVMAVAYG |
| 250 | 260 | 270 | 280 | 290 | 300 |
| LISRELYLGL | RFDEDSDSES | RVRSQGGLRG | GAGPGPAPPN | GSCRPEGGLA | GEDGDGCYVQ |
| 310 | 320 | 330 | 340 | 350 | 360 |
| LPRSRQTLEL | SALTAPTPGP | GGGPRPYQAK | LLAKKRVVRM | LLVIVVLFFL | CWLPLYSANT |
| 370 | 380 | 390 | 400 | 410 | 420 |
| WRAFDSSGAH | RALSGAPISF | IHLLSYASAC | VNPLVYCFMH | RRFRQACLET | CARCCPRPPR |
| 430 | 440 | 450 | |||
| ARPRPLPDED | PPTPSIASLS | RLSYTTISTL | GPG |