P30437

PR
Gene name
cyp17a1 (cyp17)
Protein name
Steroid 17-alpha-hydroxylase/17,20 lyase
Names
T-lymphocyte differentiation antigen T8/Leu-2, 17-alpha-hydroxyprogesterone aldolase, CYPXVII, Cytochrome P450 17A1, Cytochrome P450-C17, Cytochrome P450c17
Species
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
KEGG Pathway
omy:100137017
EC number
1.14.14.19: With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

1-79 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P30437

Entry ID Method Resolution Chain Position Source
AF-P30437-F1 Predicted AlphaFoldDB

No variants for P30437

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P30437

No associated diseases with P30437

1 regional properties for P30437

Type Name Position InterPro Accession
conserved_site Cytochrome P450, conserved site 442 - 451 IPR017972

Functions

Description
EC Number 1.14.14.19 With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
Subcellular Localization
  • Membrane
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
membrane A lipid bilayer along with all the proteins and protein complexes embedded in it an attached to it.

4 GO annotations of molecular function

Name Definition
17-alpha-hydroxyprogesterone aldolase activity Catalysis of the reaction: 17-alpha-hydroxyprogesterone = acetaldehyde + 4-androstene-3,17-dione.
heme binding Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring.
iron ion binding Binding to an iron (Fe) ion.
steroid 17-alpha-monooxygenase activity Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O.

3 GO annotations of biological process

Name Definition
progesterone metabolic process The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants.
sex differentiation The establishment of the sex of an organism by physical differentiation.
steroid biosynthetic process The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MAWFLCMCVF SVVGLGLLLL QVKLRRSLET RGGPPSLPVF PLIGSLLSLR SNQAPHVLFQ
70 80 90 100 110 120
KLQQKYGHTY SLMMGPHTVI LVNHHQHAKE VLLKKGKIFA GRPRTVTTDL LTRDGKDIAF
130 140 150 160 170 180
ADYGATWRFH RKTVHGALCM FGEGSASIEK IICREALSLC DTLRESGSAS LDLSPELTRA
190 200 210 220 230 240
VTNVVCSLCF SSSYCRGDPE FEAMLQFSQG IVDTVAKDSL VDIFPWLQVF PNADLRLLKQ
250 260 270 280 290 300
CVSIRDKLLQ KKYEEHKSDY SDHEQRDLLD ALLRAKRSAE NNNTAEITME TVGLSEDHLL
310 320 330 340 350 360
MTVGDIFGAG VETTSTVLKW AIAYLIHHPQ VQQRIQEELD SVVGGDRTPQ LSDRGSLPYL
370 380 390 400 410 420
EATIREVLRI RPVAPLLIPH VAQTDTSIGK FTVRKGARII INLWSLHHDE KEWKNPEMFD
430 440 450 460 470 480
PGRFLNEEGT GLCIPSPSYL PFGAGVRVCL GEALAKMEIF LFLSWILQRL TMTVSPGQPL
490 500 510
PSLEGKFGVV LQPVKYKVNA TPRAGWEKSH LQTS