P30317
Gene name |
pol |
Protein name |
DNA polymerase |
Names |
Vent DNA polymerase |
Species |
Thermococcus litoralis |
KEGG Pathway |
|
EC number |
2.7.7.7: Nucleotidyltransferases |
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30317
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30317-F1 | Predicted | AlphaFoldDB |
No variants for P30317
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P30317 | |||||
No associated diseases with P30317
Functions
| Description | ||
|---|---|---|
| EC Number | 2.7.7.7 | Nucleotidyltransferases |
| Subcellular Localization |
|
|
| PANTHER Family | ||
| PANTHER Subfamily | ||
| PANTHER Protein Class | ||
| PANTHER Pathway Category | No pathway information available | |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| DNA binding | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). |
| DNA-directed DNA polymerase activity | Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and a 3'hydroxyl group. |
| endonuclease activity | Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks. |
| nucleotide binding | Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. |
3 GO annotations of biological process
| Name | Definition |
|---|---|
| DNA replication | The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by initiation proteins, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. |
| intein-mediated protein splicing | The removal of an internal amino acid sequence (an intein) from a protein during protein maturation; the excision of inteins is precise and the N- and C-terminal exteins are joined by a normal peptide bond. Protein splicing involves 4 nucleophilic displacements by the 3 conserved splice junction residues. |
| intron homing | Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron. |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MILDTDYITK | DGKPIIRIFK | KENGEFKIEL | DPHFQPYIYA | LLKDDSAIEE | IKAIKGERHG |
| 70 | 80 | 90 | 100 | 110 | 120 |
| KTVRVLDAVK | VRKKFLGREV | EVWKLIFEHP | QDVPAMRGKI | REHPAVVDIY | EYDIPFAKRY |
| 130 | 140 | 150 | 160 | 170 | 180 |
| LIDKGLIPME | GDEELKLLAF | DIETFYHEGD | EFGKGEIIMI | SYADEEEARV | ITWKNIDLPY |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VDVVSNEREM | IKRFVQVVKE | KDPDVIITYN | GDNFDLPYLI | KRAEKLGVRL | VLGRDKEHPE |
| 250 | 260 | 270 | 280 | 290 | 300 |
| PKIQRMGDSF | AVEIKGRIHF | DLFPVVRRTI | NLPTYTLEAV | YEAVLGKTKS | KLGAEEIAAI |
| 310 | 320 | 330 | 340 | 350 | 360 |
| WETEESMKKL | AQYSMEDARA | TYELGKEFFP | MEAELAKLIG | QSVWDVSRSS | TGNLVEWYLL |
| 370 | 380 | 390 | 400 | 410 | 420 |
| RVAYARNELA | PNKPDEEEYK | RRLRTTYLGG | YVKEPEKGLW | ENIIYLDFRS | LYPSIIVTHN |
| 430 | 440 | 450 | 460 | 470 | 480 |
| VSPDTLEKEG | CKNYDVAPIV | GYRFCKDFPG | FIPSILGDLI | AMRQDIKKKM | KSTIDPIEKK |
| 490 | 500 | 510 | 520 | 530 | 540 |
| MLDYRQRAIK | LLANSILPNE | WLPIIENGEI | KFVKIGEFIN | SYMEKQKENV | KTVENTEVLE |
| 550 | 560 | 570 | 580 | 590 | 600 |
| VNNLFAFSFN | KKIKESEVKK | VKALIRHKYK | GKAYEIQLSS | GRKINITAGH | SLFTVRNGEI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| KEVSGDGIKE | GDLIVAPKKI | KLNEKGVSIN | IPELISDLSE | EETADIVMTI | SAKGRKNFFK |
| 670 | 680 | 690 | 700 | 710 | 720 |
| GMLRTLRWMF | GEENRRIRTF | NRYLFHLEKL | GLIKLLPRGY | EVTDWERLKK | YKQLYEKLAG |
| 730 | 740 | 750 | 760 | 770 | 780 |
| SVKYNGNKRE | YLVMFNEIKD | FISYFPQKEL | EEWKIGTLNG | FRTNCILKVD | EDFGKLLGYY |
| 790 | 800 | 810 | 820 | 830 | 840 |
| VSEGYAGAQK | NKTGGISYSV | KLYNEDPNVL | ESMKNVAEKF | FGKVRVDRNC | VSISKKMAYL |
| 850 | 860 | 870 | 880 | 890 | 900 |
| VMKCLCGALA | ENKRIPSVIL | TSPEPVRWSF | LEAYFTGDGD | IHPSKRFRLS | TKSELLANQL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| VFLLNSLGIS | SVKIGFDSGV | YRVYINEDLQ | FPQTSREKNT | YYSNLIPKEI | LRDVFGKEFQ |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| KNMTFKKFKE | LVDSGKLNRE | KAKLLEFFIN | GDIVLDRVKS | VKEKDYEGYV | YDLSVEDNEN |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| FLVGFGLLYA | HNSYYGYMGY | PKARWYSKEC | AESVTAWGRH | YIEMTIREIE | EKFGFKVLYA |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| DSVSGESEII | IRQNGKIRFV | KIKDLFSKVD | YSIGEKEYCI | LEGVEALTLD | DDGKLVWKPV |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| PYVMRHRANK | RMFRIWLTNS | WYIDVTEDHS | LIGYLNTSKT | KTAKKIGERL | KEVKPFELGK |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| AVKSLICPNA | PLKDENTKTS | EIAVKFWELV | GLIVGDGNWG | GDSRWAEYYL | GLSTGKDAEE |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| IKQKLLEPLK | TYGVISNYYP | KNEKGDFNIL | AKSLVKFMKR | HFKDEKGRRK | IPEFMYELPV |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| TYIEAFLRGL | FSADGTVTIR | KGVPEIRLTN | IDADFLREVR | KLLWIVGISN | SIFAETTPNR |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| YNGVSTGTYS | KHLRIKNKWR | FAERIGFLIE | RKQKRLLEHL | KSARVKRNTI | DFGFDLVHVK |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| KVEEIPYEGY | VYDIEVEETH | RFFANNILVH | NTDGFYATIP | GEKPELIKKK | AKEFLNYINS |
| 1510 | 1520 | 1530 | 1540 | 1550 | 1560 |
| KLPGLLELEY | EGFYLRGFFV | TKKRYAVIDE | EGRITTRGLE | VVRRDWSEIA | KETQAKVLEA |
| 1570 | 1580 | 1590 | 1600 | 1610 | 1620 |
| ILKEGSVEKA | VEVVRDVVEK | IAKYRVPLEK | LVIHEQITRD | LKDYKAIGPH | VAIAKRLAAR |
| 1630 | 1640 | 1650 | 1660 | 1670 | 1680 |
| GIKVKPGTII | SYIVLKGSGK | ISDRVILLTE | YDPRKHKYDP | DYYIENQVLP | AVLRILEAFG |
| 1690 | 1700 | ||||
| YRKEDLRYQS | SKQTGLDAWL | KR |