P30140

PR
Gene name
thiH (b3990, JW3953)
Protein name
2-iminoacetate synthase
Names
Dehydroglycine synthase, Tyrosine lyase
Species
Escherichia coli (strain K12)
KEGG Pathway
eco:b3990
EC number
4.1.99.19: Other carbon-carbon lyases
Protein Class

Descriptions

The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.

Autoinhibitory domains (AIDs)

295-376 (Predicted disordered autoinhibitory region) PR

Target domain

Relief mechanism

Assay

cis-regPred

Accessory elements

No accessory elements

References

Autoinhibited structure

Activated structure

1 structures for P30140

Entry ID Method Resolution Chain Position Source
AF-P30140-F1 Predicted AlphaFoldDB

No variants for P30140

Variant ID(s) Position Change Description Diseaes Association Provenance
No variants for P30140

No associated diseases with P30140

2 regional properties for P30140

Type Name Position InterPro Accession
domain Radical SAM 3 - 371 IPR007197
domain Biotin and thiamin synthesis-associated domain 258 - 361 IPR010722

Functions

Description
EC Number 4.1.99.19 Other carbon-carbon lyases
Subcellular Localization
PANTHER Family
PANTHER Subfamily
PANTHER Protein Class
PANTHER Pathway Category No pathway information available

1 GO annotations of cellular component

Name Definition
2-iminoacetate synthase complex A protein complex which is capable of 2-iminoacetate synthase activity.

3 GO annotations of molecular function

Name Definition
2-iminoacetate synthase activity Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+.
4 iron, 4 sulfur cluster binding Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands.
iron ion binding Binding to an iron (Fe) ion.

3 GO annotations of biological process

Name Definition
cellular response to DNA damage stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
thiamine biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.
thiamine diphosphate biosynthetic process The chemical reactions and pathways resulting in the formation of thiamine diphosphate, a derivative of thiamine (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle.

No homologous proteins in AiPD

UniProt AC Gene Name Protein Name Species Evidence Code
No homologous proteins
10 20 30 40 50 60
MKTFSDRWRQ LDWDDIRLRI NGKTAADVER ALNASQLTRD DMMALLSPAA SGYLEQLAQR
70 80 90 100 110 120
AQRLTRQRFG NTVSFYVPLY LSNLCANDCT YCGFSMSNRI KRKTLDEADI ARESAAIREM
130 140 150 160 170 180
GFEHLLLVTG EHQAKVGMDY FRRHLPALRE QFSSLQMEVQ PLAETEYAEL KQLGLDGVMV
190 200 210 220 230 240
YQETYHEATY ARHHLKGKKQ DFFWRLETPD RLGRAGIDKI GLGALIGLSD NWRVDSYMVA
250 260 270 280 290 300
EHLLWLQQHY WQSRYSVSFP RLRPCTGGIE PASIMDERQL VQTICAFRLL APEIELSLST
310 320 330 340 350 360
RESPWFRDRV IPLAINNVSA FSKTQPGGYA DNHPELEQFS PHDDRRPEAV AAALTAQGLQ
370
PVWKDWDSYL GRASQRL