P30015
Gene name |
lhr (rhlF, b1653, JW1645) |
Protein name |
Probable ATP-dependent helicase Lhr |
Names |
Large helicase-related protein |
Species |
Escherichia coli (strain K12) |
KEGG Pathway |
eco:b1653 |
EC number |
|
Protein Class |
|
Descriptions
The autoinhibited protein was predicted that may have potential autoinhibitory elements via cis-regPred.
Autoinhibitory domains (AIDs)
Target domain |
|
Relief mechanism |
|
Assay |
cis-regPred |
Accessory elements
No accessory elements
Autoinhibited structure
Activated structure
1 structures for P30015
| Entry ID | Method | Resolution | Chain | Position | Source |
|---|---|---|---|---|---|
| AF-P30015-F1 | Predicted | AlphaFoldDB |
No variants for P30015
| Variant ID(s) | Position | Change | Description | Diseaes Association | Provenance |
|---|---|---|---|---|---|
| No variants for P30015 | |||||
No associated diseases with P30015
5 regional properties for P30015
| Type | Name | Position | InterPro Accession |
|---|---|---|---|
| domain | Helicase, C-terminal | 284 - 462 | IPR001650 |
| domain | AAA+ ATPase domain | 43 - 404 | IPR003593 |
| domain | DEAD/DEAH box helicase domain | 31 - 218 | IPR011545 |
| domain | DEAD/H associated | 679 - 867 | IPR013701 |
| domain | Helicase superfamily 1/2, ATP-binding domain | 26 - 249 | IPR014001 |
No GO annotations of cellular component
| Name | Definition |
|---|---|
| No GO annotations for cellular component |
4 GO annotations of molecular function
| Name | Definition |
|---|---|
| ATP binding | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. |
| helicase activity | Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. |
| hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides | Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. |
| nucleic acid binding | Binding to a nucleic acid. |
No GO annotations of biological process
| Name | Definition |
|---|---|
| No GO annotations for biological process |
No homologous proteins in AiPD
| UniProt AC | Gene Name | Protein Name | Species | Evidence Code |
|---|---|---|---|---|
| No homologous proteins | ||||
| 10 | 20 | 30 | 40 | 50 | 60 |
| MADNPDPSSL | LPDVFSPATR | DWFLRAFKQP | TAVQPQTWHV | AARSEHALVI | APTGSGKTLA |
| 70 | 80 | 90 | 100 | 110 | 120 |
| AFLYALDRLF | REGGEDTREA | HKRKTSRILY | ISPIKALGTD | VQRNLQIPLK | GIADERRRRG |
| 130 | 140 | 150 | 160 | 170 | 180 |
| ETEVNLRVGI | RTGDTPAQER | SKLTRNPPDI | LITTPESLYL | MLTSRARETL | RGVETVIIDE |
| 190 | 200 | 210 | 220 | 230 | 240 |
| VHAVAGSKRG | AHLALSLERL | DALLHTSAQR | IGLSATVRSA | SDVAAFLGGD | RPVTVVNPPA |
| 250 | 260 | 270 | 280 | 290 | 300 |
| MRHPQIRIVV | PVANMDDVSS | VASGTGEDSH | AGREGSIWPY | IETGILDEVL | RHRSTIVFTN |
| 310 | 320 | 330 | 340 | 350 | 360 |
| SRGLAEKLTA | RLNELYAARL | QRSPSIAVDA | AHFESTSGAT | SNRVQSSDVF | IARSHHGSVS |
| 370 | 380 | 390 | 400 | 410 | 420 |
| KEQRAITEQA | LKSGELRCVV | ATSSLELGID | MGAVDLVIQV | ATPLSVASGL | QRIGRAGHQV |
| 430 | 440 | 450 | 460 | 470 | 480 |
| GGVSKGLFFP | RTRRDLVDSA | VIVECMFAGR | LENLTPPHNP | LDVLAQQTVA | AAAMDALQVD |
| 490 | 500 | 510 | 520 | 530 | 540 |
| EWYSRVRRAA | PWKDLPRRVF | DATLDMLSGR | YPSGDFSAFR | PKLVWNRETG | ILTARPGAQL |
| 550 | 560 | 570 | 580 | 590 | 600 |
| LAVTSGGTIP | DRGMYSVLLP | EGEEKAGSRR | VGELDEEMVY | ESRVNDIITL | GATSWRIQQI |
| 610 | 620 | 630 | 640 | 650 | 660 |
| TRDQVIVTPA | PGRSARLPFW | RGEGNGRPAE | LGEMIGDFLH | LLADGAFFSG | TIPPWLAEEN |
| 670 | 680 | 690 | 700 | 710 | 720 |
| TIANIQGLIE | EQRNATGIVP | GSRHLVLERC | RDEIGDWRII | LHSPYGRRVH | EPWAVAIAGR |
| 730 | 740 | 750 | 760 | 770 | 780 |
| IHALWGADAS | VVASDDGIVA | RIPDTDGKLP | DAAIFLFEPE | KLLQIVREAV | GSSALFAARF |
| 790 | 800 | 810 | 820 | 830 | 840 |
| RECAARALLM | PGRTPGHRTP | LWQQRLRASQ | LLEIAQGYPD | FPVILETLRE | CLQDVYDLPA |
| 850 | 860 | 870 | 880 | 890 | 900 |
| LERLMRRLNG | GEIQISDVTT | TTPSPFATSL | LFGYVAEFMY | QSDAPLAERR | ASVLSLDSEL |
| 910 | 920 | 930 | 940 | 950 | 960 |
| LRNLLGQVDP | GELLDPQVIR | QVEEELQRLA | PGRRAKGEEG | LFDLLRELGP | MTVEDLAQRH |
| 970 | 980 | 990 | 1000 | 1010 | 1020 |
| TGSSEEVASY | LENLLAVKRI | FPAMISGQER | LACMDDAARL | RDALGVRLPE | SLPEIYLHRV |
| 1030 | 1040 | 1050 | 1060 | 1070 | 1080 |
| SYPLRDLFLR | YLRAHALVTA | EQLAHEFSLG | IAIVEEQLQQ | LREQGLVMNL | QQDIWVSDEV |
| 1090 | 1100 | 1110 | 1120 | 1130 | 1140 |
| FRRLRLRSLQ | AAREATRPVA | ATTYARLLLE | RQGVLPATDG | SPALFASTSP | GVYEGVDGVM |
| 1150 | 1160 | 1170 | 1180 | 1190 | 1200 |
| RVIEQLAGVG | LPASLWESQI | LPARVRDYSS | EMLDELLATG | AVIWSGQKKL | GEDDGLVALH |
| 1210 | 1220 | 1230 | 1240 | 1250 | 1260 |
| LQEYAAESFT | PAEADQANRS | ALQQAIVAVL | ADGGAWFAQQ | ISQRIRDKIG | ESVDLSALQE |
| 1270 | 1280 | 1290 | 1300 | 1310 | 1320 |
| ALWALVWQGV | ITSDIWAPLR | ALTRSSSNAR | TSTRRSHRAR | RGRPVYAQPV | SPRVSYNTPN |
| 1330 | 1340 | 1350 | 1360 | 1370 | 1380 |
| LAGRWSLLQV | EPLNDTERML | ALAENMLDRY | GIISRQAVIA | ENIPGGFPSM | QTLCRSMEDS |
| 1390 | 1400 | 1410 | 1420 | 1430 | 1440 |
| GRIMRGRFVE | GLGGAQFAER | LTIDRLRDLA | TQATQTRHYT | PVALSANDPA | NVWGNLLPWP |
| 1450 | 1460 | 1470 | 1480 | 1490 | 1500 |
| AHPATLVPTR | RAGALVVVSG | GKLLLYLAQG | GKKMLVWQEK | EELLAPEVFH | ALTTALRREP |
| 1510 | 1520 | 1530 | |||
| RLRFTLTEVN | DLPVRQTPMF | TLLREAGFSS | SPQGLDWG |